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Cell Signal Transduction Research Antibodies
CD42b Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular WeightDa:68860
Protein NamePlatelet glycoprotein Ib alpha chain
Human Gene Id2811
Human Swiss Prot NoP07359
Mouse Swiss Prot NoO35930
SpecificityCD42b Polyclonal Antibody detects endogenous levels of CD42b protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGP1BA; Platelet glycoprotein Ib alpha chain; GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b-alpha; CD42b
Observed Band(KD)69
Functiondisease:Defects in GP1BA are a cause of Bernard-Soulier syndrome (BSS) [MIM:231200]; also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency.,disease:Defects in GP1BA are a cause of von Willebrand disease (vWD) [MIM:177820]; also known as platelet-type von Willebrand disease or pseudo-von Willebrand disease (pseudo-vWD). This autosomal dominant bleeding disorder is caused by an increased affinity of GP-Ib for soluble vWF resulting in impaired hemostatic function due to the removal of vWF from the circulation.,disease:Defects in GP1BA are the cause of benign mediterranean macrothrombocytopenia [MIM:153670]; also known as autosomal dominant benign Bernard-Soulier syndrome. Benign mediterranean macrothrombocytopenia is characterized by mild or no clinical symptoms, normal platelet function, and normal megakaryocyte count.
Subcellular LocationMembrane; Single-pass type I membrane protein.
ExpressionEndothelial cell,Lung,Placenta,Platelet,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human GP1BA. AA range:271-320
Gene NameGP1BA
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundglycoprotein Ib platelet alpha subunit(GP1BA) Homo sapiens Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is
Conjugated Antibody
This product is also available conjugated. Format: E20-75393-Conjugate. Price: $485 / Size: 100μl.
E20-75393-FITC$485 / 100μlE20-75393-Biotin$485 / 100μlE20-75393-HRP$485 / 100μlE20-75393-AP$485 / 100μlE20-75393-AF350$485 / 100μlE20-75393-AF405M$485 / 100μlE20-75393-AF488$485 / 100μlE20-75393-AF514$485 / 100μlE20-75393-AF532$485 / 100μlE20-75393-AF555$485 / 100μlE20-75393-AF568$485 / 100μlE20-75393-AF405S$485 / 100μlE20-75393-AF405L$485 / 100μlE20-75393-AF546$485 / 100μlE20-75393-AF594$485 / 100μlE20-75393-AF610$485 / 100μlE20-75393-AF635$485 / 100μlE20-75393-AF647$485 / 100μlE20-75393-AF680$485 / 100μlE20-75393-AF700$485 / 100μlE20-75393-AF750$485 / 100μlE20-75393-AF790$485 / 100μlE20-75393-APC$485 / 100μlE20-75393-PE$485 / 100μlE20-75393-Cy3$485 / 100μlE20-75393-Cy5$485 / 100μlE20-75393-Cy5.5$485 / 100μlE20-75393-Cy7$485 / 100μlE20-75393-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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