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Cell Signal Transduction Research Antibodies
AACT Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight47651Da
Protein NameAlpha-1-antichymotrypsin
Human Gene Id12
Human Swiss Prot NoP01011
SpecificityAACT Polyclonal Antibody detects endogenous levels of AACT protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSERPINA3; AACT; GIG24; GIG25; Alpha-1-antichymotrypsin; ACT; Cell growth-inhibiting gene 24/25 protein; Serpin A3
Observed Band(KD)46
Functioncaution:It is uncertain whether Met-1 or Met-4 is the initiator.,disease:Defects in SERPINA3 may be a cause of chronic obstructive pulmonary disease (COPD) [MIM:107280].,domain:The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.,function:Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.,miscellaneous:Alpha-1-antichymotrypsin can bind DNA.,online information:Alpha-1 antichymotrypsin entry,sequence caution:Translation N-terminally shortened.,si
Subcellular LocationSecreted.
ExpressionPlasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human SERPINA3. AA range:251-300
Gene NameSERPINA3
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundserpin family A member 3(SERPINA3) Homo sapiens The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75391-Conjugate. Price: $485 / Size: 100μl.
E20-75391-FITC$485 / 100μlE20-75391-Biotin$485 / 100μlE20-75391-HRP$485 / 100μlE20-75391-AP$485 / 100μlE20-75391-AF350$485 / 100μlE20-75391-AF405M$485 / 100μlE20-75391-AF488$485 / 100μlE20-75391-AF514$485 / 100μlE20-75391-AF532$485 / 100μlE20-75391-AF555$485 / 100μlE20-75391-AF568$485 / 100μlE20-75391-AF405S$485 / 100μlE20-75391-AF405L$485 / 100μlE20-75391-AF546$485 / 100μlE20-75391-AF594$485 / 100μlE20-75391-AF610$485 / 100μlE20-75391-AF635$485 / 100μlE20-75391-AF647$485 / 100μlE20-75391-AF680$485 / 100μlE20-75391-AF700$485 / 100μlE20-75391-AF750$485 / 100μlE20-75391-AF790$485 / 100μlE20-75391-APC$485 / 100μlE20-75391-PE$485 / 100μlE20-75391-Cy3$485 / 100μlE20-75391-Cy5$485 / 100μlE20-75391-Cy5.5$485 / 100μlE20-75391-Cy7$485 / 100μlE20-75391-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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