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Cell Signal Transduction Research Antibodies
VDAC1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight30773Da
Protein NameVoltage-dependent anion-selective channel protein 1
Human Gene Id7416
Human Swiss Prot NoP21796
Mouse Gene Id22333
Mouse Swiss Prot NoQ60932
Rat Gene Id83529
Rat Swiss Prot NoQ9Z2L0
SpecificityVDAC1 Polyclonal Antibody detects endogenous levels of VDAC1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameVDAC1; VDAC; Voltage-dependent anion-selective channel protein 1; VDAC-1; hVDAC1; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM
Observed Band(KD)31
Functiondomain:Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.,function:Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.,similarity:Belongs to the eukaryotic mitochondrial porin fami
Subcellular LocationMitochondrion outer membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Membrane raft ; Multi-pass membrane protein .
ExpressionExpressed in erythrocytes (at protein level) (PubMed:27641616). Expressed in heart, liver and skeletal muscle (PubMed:8420959).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human VDAC1. AA range:1-50
Gene NameVDAC1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundvoltage dependent anion channel 1(VDAC1) Homo sapiens This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-75390-Conjugate. Price: $485 / Size: 100μl.
E20-75390-FITC$485 / 100μlE20-75390-Biotin$485 / 100μlE20-75390-HRP$485 / 100μlE20-75390-AP$485 / 100μlE20-75390-AF350$485 / 100μlE20-75390-AF405M$485 / 100μlE20-75390-AF488$485 / 100μlE20-75390-AF514$485 / 100μlE20-75390-AF532$485 / 100μlE20-75390-AF555$485 / 100μlE20-75390-AF568$485 / 100μlE20-75390-AF405S$485 / 100μlE20-75390-AF405L$485 / 100μlE20-75390-AF546$485 / 100μlE20-75390-AF594$485 / 100μlE20-75390-AF610$485 / 100μlE20-75390-AF635$485 / 100μlE20-75390-AF647$485 / 100μlE20-75390-AF680$485 / 100μlE20-75390-AF700$485 / 100μlE20-75390-AF750$485 / 100μlE20-75390-AF790$485 / 100μlE20-75390-APC$485 / 100μlE20-75390-PE$485 / 100μlE20-75390-Cy3$485 / 100μlE20-75390-Cy5$485 / 100μlE20-75390-Cy5.5$485 / 100μlE20-75390-Cy7$485 / 100μlE20-75390-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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