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Cell Signal Transduction Research Antibodies
CacyBP Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight25080Da
Protein NameCalcyclin-binding protein
Human Gene Id27101
Human Swiss Prot NoQ9HB71
Mouse Gene Id12301
Mouse Swiss Prot NoQ9CXW3
Rat Gene Id289144
Rat Swiss Prot NoQ6AYK6
SpecificityCacyBP Polyclonal Antibody detects endogenous levels of CacyBP protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCACYBP; S100A6BP; SIP; PNAS-107; Calcyclin-binding protein; CacyBP; hCacyBP; S100A6-binding protein; Siah-interacting protein
Observed Band(KD)25
FunctionMay be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).,PTM:Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.,similarity:Contains 1 CS domain.,similarity:Contains 1 SGS domain.,subcellular location:Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.,subunit:Interacts with protein of the S100 family S100A1, S100A6, S100B, S100P and S100A12 at physiological calcium concentrations (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1, CAC
Subcellular LocationNucleus . Cytoplasm . Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.
ExpressionBrain,Colon carcinoma,Hepatoma,Liver,Promyelocytic leukemia,Skeletal muscle
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human CACYBP. AA range:171-220
Gene NameCACYBP
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundcalcyclin binding protein(CACYBP) Homo sapiens The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75389-Conjugate. Price: $485 / Size: 100μl.
E20-75389-FITC$485 / 100μlE20-75389-Biotin$485 / 100μlE20-75389-HRP$485 / 100μlE20-75389-AP$485 / 100μlE20-75389-AF350$485 / 100μlE20-75389-AF405M$485 / 100μlE20-75389-AF488$485 / 100μlE20-75389-AF514$485 / 100μlE20-75389-AF532$485 / 100μlE20-75389-AF555$485 / 100μlE20-75389-AF568$485 / 100μlE20-75389-AF405S$485 / 100μlE20-75389-AF405L$485 / 100μlE20-75389-AF546$485 / 100μlE20-75389-AF594$485 / 100μlE20-75389-AF610$485 / 100μlE20-75389-AF635$485 / 100μlE20-75389-AF647$485 / 100μlE20-75389-AF680$485 / 100μlE20-75389-AF700$485 / 100μlE20-75389-AF750$485 / 100μlE20-75389-AF790$485 / 100μlE20-75389-APC$485 / 100μlE20-75389-PE$485 / 100μlE20-75389-Cy3$485 / 100μlE20-75389-Cy5$485 / 100μlE20-75389-Cy5.5$485 / 100μlE20-75389-Cy7$485 / 100μlE20-75389-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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