17β-HSD4 Polyclonal Antibody

Name: 17β-HSD4 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75386
Price: 225 USD
Availability: InStock

E20-75386Cite ID: EN0055519Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight79686Da

Protein NamePeroxisomal multifunctional enzyme type 2

Human Gene Id3295

Human Swiss Prot NoP51659

Mouse Gene Id15488

Mouse Swiss Prot NoP51660

Rat Gene Id79244

Rat Swiss Prot NoP97852

Specificity17β-HSD4 Polyclonal Antibody detects endogenous levels of 17β-HSD4 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameHSD17B4; EDH17B4; Peroxisomal multifunctional enzyme type 2; MFE-2; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MPF-2

Observed Band(KD)80

Functioncatalytic activity:(24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl-CoA = (24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA + H(2)O.,catalytic activity:(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.,disease:Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD) [MIM:261515]. DBPD is a disorder of peroxisomal fatty acid beta-oxidation.,function:Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.,pathway:Lipid metabolism; fatty acid beta-oxidation.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,similarity:Contains 1 SCP2 domain.,tissue specificity:Present in many tissues with highest concentrations in liver, heart, prostate and testis.,

Subcellular LocationPeroxisome .

ExpressionPresent in many tissues with highest concentrations in liver, heart, prostate and testis.

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human HSD17B4. AA range:41-90

Gene NameHSD17B4

DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Backgroundhydroxysteroid 17-beta dehydrogenase 4(HSD17B4) Homo sapiens The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75386-Conjugate. Price: $485 / Size: 100μl.

E20-75386-FITC$485 / 100μlE20-75386-Biotin$485 / 100μlE20-75386-HRP$485 / 100μlE20-75386-AP$485 / 100μlE20-75386-AF350$485 / 100μlE20-75386-AF405M$485 / 100μlE20-75386-AF488$485 / 100μlE20-75386-AF514$485 / 100μlE20-75386-AF532$485 / 100μlE20-75386-AF555$485 / 100μlE20-75386-AF568$485 / 100μlE20-75386-AF405S$485 / 100μlE20-75386-AF405L$485 / 100μlE20-75386-AF546$485 / 100μlE20-75386-AF594$485 / 100μlE20-75386-AF610$485 / 100μlE20-75386-AF635$485 / 100μlE20-75386-AF647$485 / 100μlE20-75386-AF680$485 / 100μlE20-75386-AF700$485 / 100μlE20-75386-AF750$485 / 100μlE20-75386-AF790$485 / 100μlE20-75386-APC$485 / 100μlE20-75386-PE$485 / 100μlE20-75386-Cy3$485 / 100μlE20-75386-Cy5$485 / 100μlE20-75386-Cy5.5$485 / 100μlE20-75386-Cy7$485 / 100μlE20-75386-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.