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Cell Signal Transduction Research Antibodies
gp91-phox Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight65336Da
Protein NameCytochrome b-245 heavy chain
Human Gene Id1536
Human Swiss Prot NoP04839
Mouse Swiss Prot NoQ61093
Specificitygp91-phox Polyclonal Antibody detects endogenous levels of gp91-phox protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCYBB; NOX2; Cytochrome b-245 heavy chain; CGD91-phox; Cytochrome b(558) subunit beta; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2Neutrophil cytochrome b 91 kDa polypeptide; Superoxide-generating NADPH oxidase heavy chain subunit; gp91-1; gp91-phox; p22 phagocyte B-cytochrome
Observed Band(KD)70
Functioncofactor:FAD.,disease:Defects in CYBB are a cause of chronic granulomatous disease X-linked (XCGD) [MIM:306400]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.,function:Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.,online information:CYBB deficiency database,PTM:Glycosylated.,similarity:Contains 1 FAD-binding FR-t
Subcellular LocationCell membrane; Multi-pass membrane protein. As unassembled monomer may localize to the endoplasmic reticulum. .
ExpressionDetected in neutrophils (at protein level).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CYBB. AA range:111-160
Gene NameCYBB
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundcytochrome b-245 beta chain(CYBB) Homo sapiens Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75383-Conjugate. Price: $485 / Size: 100μl.
E20-75383-FITC$485 / 100μlE20-75383-Biotin$485 / 100μlE20-75383-HRP$485 / 100μlE20-75383-AP$485 / 100μlE20-75383-AF350$485 / 100μlE20-75383-AF405M$485 / 100μlE20-75383-AF488$485 / 100μlE20-75383-AF514$485 / 100μlE20-75383-AF532$485 / 100μlE20-75383-AF555$485 / 100μlE20-75383-AF568$485 / 100μlE20-75383-AF405S$485 / 100μlE20-75383-AF405L$485 / 100μlE20-75383-AF546$485 / 100μlE20-75383-AF594$485 / 100μlE20-75383-AF610$485 / 100μlE20-75383-AF635$485 / 100μlE20-75383-AF647$485 / 100μlE20-75383-AF680$485 / 100μlE20-75383-AF700$485 / 100μlE20-75383-AF750$485 / 100μlE20-75383-AF790$485 / 100μlE20-75383-APC$485 / 100μlE20-75383-PE$485 / 100μlE20-75383-Cy3$485 / 100μlE20-75383-Cy5$485 / 100μlE20-75383-Cy5.5$485 / 100μlE20-75383-Cy7$485 / 100μlE20-75383-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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