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Cell Signal Transduction Research Antibodies
Macroglobulin α-2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight163278Da
Protein NameAlpha-2-macroglobulin
Human Gene Id2
Human Swiss Prot NoP01023
SpecificityMacroglobulin α-2 Polyclonal Antibody detects endogenous levels of Macroglobulin α-2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameA2M; CPAMD5; FWP007; Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
Observed Band(KD)170
Functiondevelopmental stage:Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation.,function:Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.,online information:Alpha-2 macroglobulin entry,similarity:Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.,s
Subcellular LocationSecreted .
ExpressionSecreted in plasma.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human A2M. AA range:871-920
Gene NameA2M
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundalpha-2-macroglobulin(A2M) Homo sapiens Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75368-Conjugate. Price: $485 / Size: 100μl.
E20-75368-FITC$485 / 100μlE20-75368-Biotin$485 / 100μlE20-75368-HRP$485 / 100μlE20-75368-AP$485 / 100μlE20-75368-AF350$485 / 100μlE20-75368-AF405M$485 / 100μlE20-75368-AF488$485 / 100μlE20-75368-AF514$485 / 100μlE20-75368-AF532$485 / 100μlE20-75368-AF555$485 / 100μlE20-75368-AF568$485 / 100μlE20-75368-AF405S$485 / 100μlE20-75368-AF405L$485 / 100μlE20-75368-AF546$485 / 100μlE20-75368-AF594$485 / 100μlE20-75368-AF610$485 / 100μlE20-75368-AF635$485 / 100μlE20-75368-AF647$485 / 100μlE20-75368-AF680$485 / 100μlE20-75368-AF700$485 / 100μlE20-75368-AF750$485 / 100μlE20-75368-AF790$485 / 100μlE20-75368-APC$485 / 100μlE20-75368-PE$485 / 100μlE20-75368-Cy3$485 / 100μlE20-75368-Cy5$485 / 100μlE20-75368-Cy5.5$485 / 100μlE20-75368-Cy7$485 / 100μlE20-75368-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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