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Cell Signal Transduction Research Antibodies
IFN-αR2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight57759Da
Protein NameInterferon alpha/beta receptor 2
Human Gene Id3455
Human Swiss Prot NoP48551
Mouse Swiss Prot NoO35664
SpecificityIFN-αR2 Polyclonal Antibody detects endogenous levels of IFN-αR2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameIFNAR2; IFNABR; IFNARB; Interferon alpha/beta receptor 2; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2; Interferon alpha binding protein; Type I interferon receptor 2
Observed Band(KD)57
Functiondisease:Defects in IFNAR2 are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.,function:Receptor for interferons alpha and beta. Isoform 1 and isoform 3 are directly involved in signal transduction due to their interaction with the TYR kinase, JAK1. Isoform 1 also interacts with the transcriptional factors, STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity.,PTM:Upon binding, it is phosphorylated on tyrosine residues.,similarity:Belongs to the type II cytokine receptor family.,
Subcellular Location[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 3]: Secreted .
ExpressionIsoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human IFNAR2. AA range:41-90
Gene NameIFNAR2
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundinterferon alpha and beta receptor subunit 2(IFNAR2) Homo sapiens The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75367-Conjugate. Price: $485 / Size: 100μl.
E20-75367-FITC$485 / 100μlE20-75367-Biotin$485 / 100μlE20-75367-HRP$485 / 100μlE20-75367-AP$485 / 100μlE20-75367-AF350$485 / 100μlE20-75367-AF405M$485 / 100μlE20-75367-AF488$485 / 100μlE20-75367-AF514$485 / 100μlE20-75367-AF532$485 / 100μlE20-75367-AF555$485 / 100μlE20-75367-AF568$485 / 100μlE20-75367-AF405S$485 / 100μlE20-75367-AF405L$485 / 100μlE20-75367-AF546$485 / 100μlE20-75367-AF594$485 / 100μlE20-75367-AF610$485 / 100μlE20-75367-AF635$485 / 100μlE20-75367-AF647$485 / 100μlE20-75367-AF680$485 / 100μlE20-75367-AF700$485 / 100μlE20-75367-AF750$485 / 100μlE20-75367-AF790$485 / 100μlE20-75367-APC$485 / 100μlE20-75367-PE$485 / 100μlE20-75367-Cy3$485 / 100μlE20-75367-Cy5$485 / 100μlE20-75367-Cy5.5$485 / 100μlE20-75367-Cy7$485 / 100μlE20-75367-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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