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Cell Signal Transduction Research Antibodies
Ang-1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight57513Da
Protein NameAngiopoietin-1
Human Gene Id284
Human Swiss Prot NoQ15389
Mouse Swiss Prot NoO08538
Rat Gene Id89807
Rat Swiss Prot NoO35460
SpecificityAng-1 Polyclonal Antibody detects endogenous levels of Ang-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameANGPT1; KIAA0003; Angiopoietin-1; ANG-1
Observed Band(KD)57
FunctionBinds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.,miscellaneous:It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart.,online information:Angiopoietin entry,PTM:Glycosylated.,similarity:Contains 1 fibrinogen C-terminal domain.,
Subcellular LocationSecreted.
ExpressionBone marrow,Clones donated by Kazusa DNA Research Inst.,Fetal lung,Prostate,Small intestine
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human ANGPT1. AA range:1-50
Gene NameANGPT1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundangiopoietin 1(ANGPT1) Homo sapiens This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-75365-Conjugate. Price: $485 / Size: 100μl.
E20-75365-FITC$485 / 100μlE20-75365-Biotin$485 / 100μlE20-75365-HRP$485 / 100μlE20-75365-AP$485 / 100μlE20-75365-AF350$485 / 100μlE20-75365-AF405M$485 / 100μlE20-75365-AF488$485 / 100μlE20-75365-AF514$485 / 100μlE20-75365-AF532$485 / 100μlE20-75365-AF555$485 / 100μlE20-75365-AF568$485 / 100μlE20-75365-AF405S$485 / 100μlE20-75365-AF405L$485 / 100μlE20-75365-AF546$485 / 100μlE20-75365-AF594$485 / 100μlE20-75365-AF610$485 / 100μlE20-75365-AF635$485 / 100μlE20-75365-AF647$485 / 100μlE20-75365-AF680$485 / 100μlE20-75365-AF700$485 / 100μlE20-75365-AF750$485 / 100μlE20-75365-AF790$485 / 100μlE20-75365-APC$485 / 100μlE20-75365-PE$485 / 100μlE20-75365-Cy3$485 / 100μlE20-75365-Cy5$485 / 100μlE20-75365-Cy5.5$485 / 100μlE20-75365-Cy7$485 / 100μlE20-75365-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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