World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
NTE Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight149995Da
Protein NameNeuropathy target esterase
Human Gene Id10908
Human Swiss Prot NoQ8IY17
Mouse Gene Id50767
Mouse Swiss Prot NoQ3TRM4
SpecificityNTE Polyclonal Antibody detects endogenous levels of NTE protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePNPLA6; NTE; Neuropathy target esterase; Patatin-like phospholipase domain-containing protein 6
Observed Band(KD)150
Functioncatalytic activity:2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.,disease:Defects in PNPLA6 are the cause of spastic paraplegia autosomal recessive type 39 (SPG39) [MIM:612020]; also known as NTE-related motor neuron disorder (NTEMND). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG39 is associated with a motor axonopathy affecting upper and lower limbs and resulting in progressive wasting of distal upper and
Subcellular LocationEndoplasmic reticulum membrane ; Single-pass type III membrane protein .
ExpressionExpressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human PNPLA6. AA range:1031-1080
Gene NamePNPLA6
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundpatatin like phospholipase domain containing 6(PNPLA6) Homo sapiens This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],
Conjugated Antibody
This product is also available conjugated. Format: E20-75363-Conjugate. Price: $485 / Size: 100μl.
E20-75363-FITC$485 / 100μlE20-75363-Biotin$485 / 100μlE20-75363-HRP$485 / 100μlE20-75363-AP$485 / 100μlE20-75363-AF350$485 / 100μlE20-75363-AF405M$485 / 100μlE20-75363-AF488$485 / 100μlE20-75363-AF514$485 / 100μlE20-75363-AF532$485 / 100μlE20-75363-AF555$485 / 100μlE20-75363-AF568$485 / 100μlE20-75363-AF405S$485 / 100μlE20-75363-AF405L$485 / 100μlE20-75363-AF546$485 / 100μlE20-75363-AF594$485 / 100μlE20-75363-AF610$485 / 100μlE20-75363-AF635$485 / 100μlE20-75363-AF647$485 / 100μlE20-75363-AF680$485 / 100μlE20-75363-AF700$485 / 100μlE20-75363-AF750$485 / 100μlE20-75363-AF790$485 / 100μlE20-75363-APC$485 / 100μlE20-75363-PE$485 / 100μlE20-75363-Cy3$485 / 100μlE20-75363-Cy5$485 / 100μlE20-75363-Cy5.5$485 / 100μlE20-75363-Cy7$485 / 100μlE20-75363-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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