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Cell Signal Transduction Research Antibodies
Troponin T-C Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight35924Da
Protein NameTroponin T cardiac muscle
Human Gene Id7139
Human Swiss Prot NoP45379
Mouse Gene Id21956
Mouse Swiss Prot NoP50752
Rat Gene Id24837
Rat Swiss Prot NoP50753
SpecificityTroponin T-C Polyclonal Antibody detects endogenous levels of Troponin T-C protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTNNT2; Troponin T, cardiac muscle; TnTc; Cardiac muscle troponin T; cTnT
Observed Band(KD)35
Functionalternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,disease:Defects in TNNT2 are the cause of cardiomyopathy dilated type 1D (CMD1D) [MIM:601494]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,disease:Defects in TNNT2 are the cause of cardiomyopathy familial hypertrophic type 2 (CMH2) [MIM:115195]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign
Subcellular Locationcytosol,troponin complex,striated muscle thin filament,sarcomere,
ExpressionHeart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human TNNT2. AA range:131-180
Gene NameTNNT2
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundtroponin T2, cardiac type(TNNT2) Homo sapiens The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75362-Conjugate. Price: $485 / Size: 100μl.
E20-75362-FITC$485 / 100μlE20-75362-Biotin$485 / 100μlE20-75362-HRP$485 / 100μlE20-75362-AP$485 / 100μlE20-75362-AF350$485 / 100μlE20-75362-AF405M$485 / 100μlE20-75362-AF488$485 / 100μlE20-75362-AF514$485 / 100μlE20-75362-AF532$485 / 100μlE20-75362-AF555$485 / 100μlE20-75362-AF568$485 / 100μlE20-75362-AF405S$485 / 100μlE20-75362-AF405L$485 / 100μlE20-75362-AF546$485 / 100μlE20-75362-AF594$485 / 100μlE20-75362-AF610$485 / 100μlE20-75362-AF635$485 / 100μlE20-75362-AF647$485 / 100μlE20-75362-AF680$485 / 100μlE20-75362-AF700$485 / 100μlE20-75362-AF750$485 / 100μlE20-75362-AF790$485 / 100μlE20-75362-APC$485 / 100μlE20-75362-PE$485 / 100μlE20-75362-Cy3$485 / 100μlE20-75362-Cy5$485 / 100μlE20-75362-Cy5.5$485 / 100μlE20-75362-Cy7$485 / 100μlE20-75362-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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