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Cell Signal Transduction Research Antibodies
Arg Polyclonal Antibody
：Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight：128343Da
Protein Name：Abelson tyrosine-protein kinase 2
Human Gene Id：27
Human Swiss Prot No：P42684
Mouse Swiss Prot No：Q4JIM5
Specificity：Arg Polyclonal Antibody detects endogenous levels of Arg protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration：1 mg/ml
Storage Stability：-20°C/1 year
Other Name：ABL2; ABLL; ARG; Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG
Observed Band(KD)：130
Function：catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Magnesium or manganese.,enzyme regulation:Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the amino-terminal cap, and contributions from an amino-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML).,function:Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosph
Subcellular Location：Cytoplasm, cytoskeleton.
Expression：Widely expressed.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human ABL2. AA range:601-650
Gene Name：ABL2
Dilution：Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Background：ABL proto-oncogene 2, non-receptor tyrosine kinase(ABL2) Homo sapiens This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009],
Conjugated Antibody
This product is also available conjugated. Format: E20-75358-Conjugate. Price: $485 / Size: 100μl.
E20-75358-FITC$485 / 100μlE20-75358-Biotin$485 / 100μlE20-75358-HRP$485 / 100μlE20-75358-AP$485 / 100μlE20-75358-AF350$485 / 100μlE20-75358-AF405M$485 / 100μlE20-75358-AF488$485 / 100μlE20-75358-AF514$485 / 100μlE20-75358-AF532$485 / 100μlE20-75358-AF555$485 / 100μlE20-75358-AF568$485 / 100μlE20-75358-AF405S$485 / 100μlE20-75358-AF405L$485 / 100μlE20-75358-AF546$485 / 100μlE20-75358-AF594$485 / 100μlE20-75358-AF610$485 / 100μlE20-75358-AF635$485 / 100μlE20-75358-AF647$485 / 100μlE20-75358-AF680$485 / 100μlE20-75358-AF700$485 / 100μlE20-75358-AF750$485 / 100μlE20-75358-AF790$485 / 100μlE20-75358-APC$485 / 100μlE20-75358-PE$485 / 100μlE20-75358-Cy3$485 / 100μlE20-75358-Cy5$485 / 100μlE20-75358-Cy5.5$485 / 100μlE20-75358-Cy7$485 / 100μlE20-75358-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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