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Cell Signal Transduction Research Antibodies
RUNX2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight56648Da
Protein NameRunt-related transcription factor 2
Human Gene Id860
Human Swiss Prot NoQ13950
Mouse Gene Id12393
Mouse Swiss Prot NoQ08775
Rat Swiss Prot NoQ9Z2J9
SpecificityRUNX2 Polyclonal Antibody detects endogenous levels of RUNX2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameRUNX2; AML3; CBFA1; OSF2; PEBP2A; Runt-related transcription factor 2; Acute myeloid leukemia 3 protein; Core-binding factor subunit alpha-1; CBF-alpha-1; Oncogene AML-3Osteoblast-specific transcription factor 2; OSF-2; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEA2-alpha A; PEBP2-alpha A; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit
Observed Band(KD)56
Functiondisease:Defects in RUNX2 are the cause of cleidocranial dysplasia (CCD) [MIM:119600]. CCD is an autosomal dominant skeletal disorder with high penetrance and variable expressivity. It is due to defective endochondral and intramembranous bone formation. Typical features include hypoplasia/aplasia of clavicles, patent fontanelles, wormian bones (additional cranial plates caused by abnormal ossification of the calvaria), supernumerary teeth, short stature, and other skeletal changes. In some cases defects in RUNX2 are exclusively associated with dental anomalies.,domain:A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes and contains the phosphorylation sites.,function:Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous a
Subcellular LocationNucleus .
ExpressionSpecifically expressed in osteoblasts.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human RUNX2. AA range:201-250
Gene NameRUNX2
DilutionIF: 1:50-200 Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundrunt related transcription factor 2(RUNX2) Homo sapiens This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016],
Conjugated Antibody
This product is also available conjugated. Format: E20-75356-Conjugate. Price: $485 / Size: 100μl.
E20-75356-FITC$485 / 100μlE20-75356-Biotin$485 / 100μlE20-75356-HRP$485 / 100μlE20-75356-AP$485 / 100μlE20-75356-AF350$485 / 100μlE20-75356-AF405M$485 / 100μlE20-75356-AF488$485 / 100μlE20-75356-AF514$485 / 100μlE20-75356-AF532$485 / 100μlE20-75356-AF555$485 / 100μlE20-75356-AF568$485 / 100μlE20-75356-AF405S$485 / 100μlE20-75356-AF405L$485 / 100μlE20-75356-AF546$485 / 100μlE20-75356-AF594$485 / 100μlE20-75356-AF610$485 / 100μlE20-75356-AF635$485 / 100μlE20-75356-AF647$485 / 100μlE20-75356-AF680$485 / 100μlE20-75356-AF700$485 / 100μlE20-75356-AF750$485 / 100μlE20-75356-AF790$485 / 100μlE20-75356-APC$485 / 100μlE20-75356-PE$485 / 100μlE20-75356-Cy3$485 / 100μlE20-75356-Cy5$485 / 100μlE20-75356-Cy5.5$485 / 100μlE20-75356-Cy7$485 / 100μlE20-75356-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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