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Cell Signal Transduction Research Antibodies
ALDH2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight56381Da
Protein NameAldehyde dehydrogenase mitochondrial
Human Gene Id217
Human Swiss Prot NoP05091
Mouse Gene Id11669
Mouse Swiss Prot NoP47738
Rat Gene Id29539
Rat Swiss Prot NoP11884
SpecificityALDH2 Polyclonal Antibody detects endogenous levels of ALDH2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameALDH2; ALDM; Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI
Observed Band(KD)56
Functioncatalytic activity:An aldehyde + NAD(+) + H(2)O = an acid + NADH.,disease:Defects in ALDH2 are a cause of acute alcohol sensitivity [MIM:610251]. There are wide individual differences in responses to drinking alcohol. Recent estimates claim that subjective effects (how people feel when they drink) vary from 200%-300% in the adult population, and ethanol metabolism (how quickly alcohol is absorbed into the bloodstream and metabolized by the liver) varies by approximately 200%. Unfortunately, alcohol researchers know very little about why such drastic differences occur between individuals and how individual differences in alcohol sensitivity might link drinking behavior with problematic alcohol-related outcomes.,pathway:Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.,polymorphism:Allele ALDH2*2 is associated with a very high incidence of acute alcohol intoxication
Subcellular LocationMitochondrion matrix.
ExpressionAdipocyte,Brain,Cajal-Retzius cell,Liver,Lymph,Muscle,Small
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human ALDH2. AA range:41-90
Gene NameALDH2
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundaldehyde dehydrogenase 2 family (mitochondrial)(ALDH2) Homo sapiens This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform,
Conjugated Antibody
This product is also available conjugated. Format: E20-75355-Conjugate. Price: $485 / Size: 100μl.
E20-75355-FITC$485 / 100μlE20-75355-Biotin$485 / 100μlE20-75355-HRP$485 / 100μlE20-75355-AP$485 / 100μlE20-75355-AF350$485 / 100μlE20-75355-AF405M$485 / 100μlE20-75355-AF488$485 / 100μlE20-75355-AF514$485 / 100μlE20-75355-AF532$485 / 100μlE20-75355-AF555$485 / 100μlE20-75355-AF568$485 / 100μlE20-75355-AF405S$485 / 100μlE20-75355-AF405L$485 / 100μlE20-75355-AF546$485 / 100μlE20-75355-AF594$485 / 100μlE20-75355-AF610$485 / 100μlE20-75355-AF635$485 / 100μlE20-75355-AF647$485 / 100μlE20-75355-AF680$485 / 100μlE20-75355-AF700$485 / 100μlE20-75355-AF750$485 / 100μlE20-75355-AF790$485 / 100μlE20-75355-APC$485 / 100μlE20-75355-PE$485 / 100μlE20-75355-Cy3$485 / 100μlE20-75355-Cy5$485 / 100μlE20-75355-Cy5.5$485 / 100μlE20-75355-Cy7$485 / 100μlE20-75355-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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