World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
MPO Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight83869Da
Protein NameMyeloperoxidase
Human Gene Id4353
Human Swiss Prot NoP05164
Mouse Gene Id17523
Mouse Swiss Prot NoP11247
SpecificityMPO Polyclonal Antibody detects endogenous levels of MPO protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMPO; Myeloperoxidase; MPO
Observed Band(KD)85
Functioncatalytic activity:Cl(-) + H(2)O(2) = HOCl + 2 H(2)O.,catalytic activity:Donor + H(2)O(2) = oxidized donor + 2 H(2)O.,cofactor:Binds 1 calcium ion per heterodimer.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.,disease:Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.,function:Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.,online information:MPO mutation db,online information:Myeloperoxidase entry,similarity:Belongs to the peroxidase family. XPO sub
Subcellular LocationLysosome.
ExpressionLeukemia,Leukocyte,Liver,Plasma,Saliva,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human MPO. AA range:41-90
Gene NameMPO
DilutionIHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundmyeloperoxidase(MPO) Homo sapiens Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014],
Conjugated Antibody
This product is also available conjugated. Format: E20-75351-Conjugate. Price: $485 / Size: 100μl.
E20-75351-FITC$485 / 100μlE20-75351-Biotin$485 / 100μlE20-75351-HRP$485 / 100μlE20-75351-AP$485 / 100μlE20-75351-AF350$485 / 100μlE20-75351-AF405M$485 / 100μlE20-75351-AF488$485 / 100μlE20-75351-AF514$485 / 100μlE20-75351-AF532$485 / 100μlE20-75351-AF555$485 / 100μlE20-75351-AF568$485 / 100μlE20-75351-AF405S$485 / 100μlE20-75351-AF405L$485 / 100μlE20-75351-AF546$485 / 100μlE20-75351-AF594$485 / 100μlE20-75351-AF610$485 / 100μlE20-75351-AF635$485 / 100μlE20-75351-AF647$485 / 100μlE20-75351-AF680$485 / 100μlE20-75351-AF700$485 / 100μlE20-75351-AF750$485 / 100μlE20-75351-AF790$485 / 100μlE20-75351-APC$485 / 100μlE20-75351-PE$485 / 100μlE20-75351-Cy3$485 / 100μlE20-75351-Cy5$485 / 100μlE20-75351-Cy5.5$485 / 100μlE20-75351-Cy7$485 / 100μlE20-75351-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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