World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
CD10 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight85514Da
Protein NameNeprilysin
Human Gene Id4311
Human Swiss Prot NoP08473
Mouse Gene Id17380
Mouse Swiss Prot NoQ61391
Rat Gene Id24590
Rat Swiss Prot NoP07861
SpecificityCD10 Polyclonal Antibody detects endogenous levels of CD10 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMME; EPN; Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD10
Observed Band(KD)85
Functioncatalytic activity:Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.,cofactor:Binds 1 zinc ion per subunit.,disease:Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.,enzyme regulation:Inhibited in a dose dependent manner by opiorphin.,function:Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradation of atrial natriuretic factor (ANF).,similarity:Belongs to the peptidase M13 family.,
Subcellular LocationCell membrane; Single-pass type II membrane protein.
ExpressionAdrenal cortex,Brain,Kidney,Placenta,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human MME. AA range:491-540
Gene NameMME
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundmembrane metalloendopeptidase(MME) Homo sapiens This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this
Conjugated Antibody
This product is also available conjugated. Format: E20-75350-Conjugate. Price: $485 / Size: 100μl.
E20-75350-FITC$485 / 100μlE20-75350-Biotin$485 / 100μlE20-75350-HRP$485 / 100μlE20-75350-AP$485 / 100μlE20-75350-AF350$485 / 100μlE20-75350-AF405M$485 / 100μlE20-75350-AF488$485 / 100μlE20-75350-AF514$485 / 100μlE20-75350-AF532$485 / 100μlE20-75350-AF555$485 / 100μlE20-75350-AF568$485 / 100μlE20-75350-AF405S$485 / 100μlE20-75350-AF405L$485 / 100μlE20-75350-AF546$485 / 100μlE20-75350-AF594$485 / 100μlE20-75350-AF610$485 / 100μlE20-75350-AF635$485 / 100μlE20-75350-AF647$485 / 100μlE20-75350-AF680$485 / 100μlE20-75350-AF700$485 / 100μlE20-75350-AF750$485 / 100μlE20-75350-AF790$485 / 100μlE20-75350-APC$485 / 100μlE20-75350-PE$485 / 100μlE20-75350-Cy3$485 / 100μlE20-75350-Cy5$485 / 100μlE20-75350-Cy5.5$485 / 100μlE20-75350-Cy7$485 / 100μlE20-75350-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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