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Cell Signal Transduction Research Antibodies
IL-6 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight21~30Da
Protein NameInterleukin-6
Human Gene Id3569
Human Swiss Prot NoP05231
Mouse Swiss Prot NoP08505
SpecificityIL-6 Polyclonal Antibody detects endogenous levels of IL-6 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameIL6; IFNB2; Interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2
Observed Band(KD)23
Functiondisease:At least 1 polymorphism in the IL6 gene renders HIV-infected men susceptible to Kaposi sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue. A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS.,disease:Genetic variations in IL6 are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement.,function:IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the
Subcellular LocationSecreted .
ExpressionProduced by skeletal muscle.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human IL6. AA range:131-180
Gene NameIL6
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.
Backgroundinterleukin 6(IL6) Homo sapiens This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-75348-Conjugate. Price: $485 / Size: 100μl.
E20-75348-FITC$485 / 100μlE20-75348-Biotin$485 / 100μlE20-75348-HRP$485 / 100μlE20-75348-AP$485 / 100μlE20-75348-AF350$485 / 100μlE20-75348-AF405M$485 / 100μlE20-75348-AF488$485 / 100μlE20-75348-AF514$485 / 100μlE20-75348-AF532$485 / 100μlE20-75348-AF555$485 / 100μlE20-75348-AF568$485 / 100μlE20-75348-AF405S$485 / 100μlE20-75348-AF405L$485 / 100μlE20-75348-AF546$485 / 100μlE20-75348-AF594$485 / 100μlE20-75348-AF610$485 / 100μlE20-75348-AF635$485 / 100μlE20-75348-AF647$485 / 100μlE20-75348-AF680$485 / 100μlE20-75348-AF700$485 / 100μlE20-75348-AF750$485 / 100μlE20-75348-AF790$485 / 100μlE20-75348-APC$485 / 100μlE20-75348-PE$485 / 100μlE20-75348-Cy3$485 / 100μlE20-75348-Cy5$485 / 100μlE20-75348-Cy5.5$485 / 100μlE20-75348-Cy7$485 / 100μlE20-75348-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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