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Cell Signal Transduction Research Antibodies
p73 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight69623Da
Protein NameTumor protein p73
Human Gene Id7161
Human Swiss Prot NoO15350
Mouse Swiss Prot NoQ9JJP2
Specificityp73 Polyclonal Antibody detects endogenous levels of p73 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTP73; P73; Tumor protein p73; p53-like transcription factor; p53-related protein
Observed Band(KD)70
Functioncofactor:Binds 1 zinc ion per subunit.,disease:Maps to a chromosome region frequently mutated in diverse cell lines of human cancer. Appears not to be frequently mutated in human cancers, in contrast to p53. Hemizygosity is observed in neuroblastoma and oligodendroglioma.,domain:Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL tyrosine kinase SH3 domain.,domain:The WW-binding motif mediates interaction with WWOX.,function:Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.,induction:Not induced by DNA damage. Isoforms lacking the transactivation domain block gene induction.,miscellaneous:Activ
Subcellular LocationNucleus . Cytoplasm. Accumulates in the nucleus in response to DNA damage.
ExpressionExpressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue. Expressed in the respiratory epithelium (PubMed:34077761).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human p73 around the non-acetylation site of Lys321. AA range:281-330
Gene NameTP73
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundtumor protein p73(TP73) Homo sapiens This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75343-Conjugate. Price: $485 / Size: 100μl.
E20-75343-FITC$485 / 100μlE20-75343-Biotin$485 / 100μlE20-75343-HRP$485 / 100μlE20-75343-AP$485 / 100μlE20-75343-AF350$485 / 100μlE20-75343-AF405M$485 / 100μlE20-75343-AF488$485 / 100μlE20-75343-AF514$485 / 100μlE20-75343-AF532$485 / 100μlE20-75343-AF555$485 / 100μlE20-75343-AF568$485 / 100μlE20-75343-AF405S$485 / 100μlE20-75343-AF405L$485 / 100μlE20-75343-AF546$485 / 100μlE20-75343-AF594$485 / 100μlE20-75343-AF610$485 / 100μlE20-75343-AF635$485 / 100μlE20-75343-AF647$485 / 100μlE20-75343-AF680$485 / 100μlE20-75343-AF700$485 / 100μlE20-75343-AF750$485 / 100μlE20-75343-AF790$485 / 100μlE20-75343-APC$485 / 100μlE20-75343-PE$485 / 100μlE20-75343-Cy3$485 / 100μlE20-75343-Cy5$485 / 100μlE20-75343-Cy5.5$485 / 100μlE20-75343-Cy7$485 / 100μlE20-75343-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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