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Cell Signal Transduction Research Antibodies
Nrf2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight75-100Da
Protein NameNuclear factor erythroid 2-related factor 2
Human Gene Id4780
Human Swiss Prot NoQ16236
Mouse Gene Id18024
Mouse Swiss Prot NoQ60795
Rat Gene Id83619
Rat Swiss Prot NoO54968
SpecificityNrf2 Polyclonal Antibody detects endogenous levels of Nrf2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNFE2L2; NRF2; Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2
Observed Band(KD)75-100
Functiondomain:Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus.,function:Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.,PTM:Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. CNC subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electr
Subcellular LocationCytoplasm, cytosol . Nucleus . Cytosolic under unstressed conditions: ubiquitinated and degraded by the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:15601839, PubMed:21196497). Translocates into the nucleus upon induction by electrophilic agents that inactivate the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:21196497). .
ExpressionWidely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human NFE2L2 around the non-acetylation site of Lys599. AA range:556-605
Gene NameNFE2L2
DilutionIF: 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300
Backgroundnuclear factor, erythroid 2 like 2(NFE2L2) Homo sapiens This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-75337-Conjugate. Price: $485 / Size: 100μl.
E20-75337-FITC$485 / 100μlE20-75337-Biotin$485 / 100μlE20-75337-HRP$485 / 100μlE20-75337-AP$485 / 100μlE20-75337-AF350$485 / 100μlE20-75337-AF405M$485 / 100μlE20-75337-AF488$485 / 100μlE20-75337-AF514$485 / 100μlE20-75337-AF532$485 / 100μlE20-75337-AF555$485 / 100μlE20-75337-AF568$485 / 100μlE20-75337-AF405S$485 / 100μlE20-75337-AF405L$485 / 100μlE20-75337-AF546$485 / 100μlE20-75337-AF594$485 / 100μlE20-75337-AF610$485 / 100μlE20-75337-AF635$485 / 100μlE20-75337-AF647$485 / 100μlE20-75337-AF680$485 / 100μlE20-75337-AF700$485 / 100μlE20-75337-AF750$485 / 100μlE20-75337-AF790$485 / 100μlE20-75337-APC$485 / 100μlE20-75337-PE$485 / 100μlE20-75337-Cy3$485 / 100μlE20-75337-Cy5$485 / 100μlE20-75337-Cy5.5$485 / 100μlE20-75337-Cy7$485 / 100μlE20-75337-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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