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Cell Signal Transduction Research Antibodies
Ku-70 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight69843Da
Protein NameX-ray repair cross-complementing protein 6
Human Gene Id2547
Human Swiss Prot NoP12956
Mouse Swiss Prot NoP23475
SpecificityKu-70 Polyclonal Antibody detects endogenous levels of Ku-70 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameXRCC6; G22P1; X-ray repair cross-complementing protein 6; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit;CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6
Observed Band(KD)70
Functiondevelopmental stage:Expression does not increase during promyelocyte differentiation.,disease:Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely large amounts of autoantibodies to p70 and p86. Existence of a major autoantigenic epitope or epitopes on the C-terminal 190 amino acids of p70 containing the leucine repeat. The majority of autoantibodies to p70 in most sera from patients with SLE seem to be reactive with this region.,function:Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by p70. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The Ku p70/p86
Subcellular LocationNucleus . Chromosome .
ExpressionBrain,Cervix carcinoma,Epithelium,Heart,Hepatocyte,Kidney,Liver,Lu
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Ku70 around the non-acetylation site of Lys539. AA range:501-550
Gene NameXRCC6
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
BackgroundX-ray repair cross complementing 6(XRCC6) Homo sapiens The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75333-Conjugate. Price: $485 / Size: 100μl.
E20-75333-FITC$485 / 100μlE20-75333-Biotin$485 / 100μlE20-75333-HRP$485 / 100μlE20-75333-AP$485 / 100μlE20-75333-AF350$485 / 100μlE20-75333-AF405M$485 / 100μlE20-75333-AF488$485 / 100μlE20-75333-AF514$485 / 100μlE20-75333-AF532$485 / 100μlE20-75333-AF555$485 / 100μlE20-75333-AF568$485 / 100μlE20-75333-AF405S$485 / 100μlE20-75333-AF405L$485 / 100μlE20-75333-AF546$485 / 100μlE20-75333-AF594$485 / 100μlE20-75333-AF610$485 / 100μlE20-75333-AF635$485 / 100μlE20-75333-AF647$485 / 100μlE20-75333-AF680$485 / 100μlE20-75333-AF700$485 / 100μlE20-75333-AF750$485 / 100μlE20-75333-AF790$485 / 100μlE20-75333-APC$485 / 100μlE20-75333-PE$485 / 100μlE20-75333-Cy3$485 / 100μlE20-75333-Cy5$485 / 100μlE20-75333-Cy5.5$485 / 100μlE20-75333-Cy7$485 / 100μlE20-75333-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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