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Cell Signal Transduction Research Antibodies
Keratin-pan Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight65865Da
Protein NameKeratin, type II cytoskeletal 2 epidermal
Human Gene Id3849
Human Swiss Prot NoP35908
Mouse Gene Id16681
Mouse Swiss Prot NoQ3TTY5
Rat Gene Id406228
Rat Swiss Prot NoQ6IG02
SpecificityKeratin-pan Polyclonal Antibody detects endogenous levels of Keratin-pan protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameKRT2; KRT76; KRT3; KRT5; KRT6A; KRT6B; KRT6C; KRT71; KRT72; KRT73; KRT74; KRT75; KRT79; KRT8; KRT84; Keratin, type II cytoskeletal 2 epidermal; Keratin, type II cytoskeletal 2 oral; Keratin, type II cytoskeletal 3; Keratin, type II cytoskeletal 5;Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 6B; Keratin, type II cytoskeletal 6C; Keratin, type II cytoskeletal 71; Keratin, type II cytoskeletal 72; Keratin, type II cytoskeletal 73; Keratin, type II cytoskeletal 74;
Observed Band(KD)65
Functiondevelopmental stage:Synthesized during maturation of epidermal keratinocytes and localized in the upper intermediate cells of fetal skin. Earliest expression is at 10 weeks in the developing embryo in the presumptive nail bed of developing digits, shifting to the proximal nail fold by 13.5 weeks. At 12.5 weeks, detected in scattered cells of the intermediate layer of trunk skin. At 19.3 weeks, regional expression patterns were observed in upper intermediate keratinocytes of cheek, trunk, dorsal and ventral knee, elbow and dorsal hand. Distal areas around the periumbilical region showed increased number of positive cells and by 15 weeks is expressed in small groups of cells in the fetal hair follicles.,disease:Defects in KRT2 are a cause of ichthyosis bullosa of Siemens (IBS) [MIM:146800]. IBS is a rare autosomal dominant skin disorder displaying a type of epidermolytic hyperkeratosis cha
Subcellular Locationextracellular space,nucleus,cytoplasm,Golgi apparatus,intermediate filament,membrane,keratin filament,intermediate filament cytoskeleton,extracellular exosome,
ExpressionExpressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Keratin around the non-acetylation site of Lys185 AND OTHERS. AA range:151-200
Gene NameKRT2
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundkeratin 2(KRT2) Homo sapiens The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75329-Conjugate. Price: $485 / Size: 100μl.
E20-75329-FITC$485 / 100μlE20-75329-Biotin$485 / 100μlE20-75329-HRP$485 / 100μlE20-75329-AP$485 / 100μlE20-75329-AF350$485 / 100μlE20-75329-AF405M$485 / 100μlE20-75329-AF488$485 / 100μlE20-75329-AF514$485 / 100μlE20-75329-AF532$485 / 100μlE20-75329-AF555$485 / 100μlE20-75329-AF568$485 / 100μlE20-75329-AF405S$485 / 100μlE20-75329-AF405L$485 / 100μlE20-75329-AF546$485 / 100μlE20-75329-AF594$485 / 100μlE20-75329-AF610$485 / 100μlE20-75329-AF635$485 / 100μlE20-75329-AF647$485 / 100μlE20-75329-AF680$485 / 100μlE20-75329-AF700$485 / 100μlE20-75329-AF750$485 / 100μlE20-75329-AF790$485 / 100μlE20-75329-APC$485 / 100μlE20-75329-PE$485 / 100μlE20-75329-Cy3$485 / 100μlE20-75329-Cy5$485 / 100μlE20-75329-Cy5.5$485 / 100μlE20-75329-Cy7$485 / 100μlE20-75329-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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