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Cell Signal Transduction Research Antibodies
ERα Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight66216Da
Protein NameEstrogen receptor
Human Gene Id2099
Human Swiss Prot NoP03372
Mouse Swiss Prot NoP19785
SpecificityERα Polyclonal Antibody detects endogenous levels of ERα protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameESR1; ESR; NR3A1; Estrogen receptor; ER; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
Observed Band(KD)66
Functiondomain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.,online information:Estrogen receptor entry,polymorphism:Genetic variations in ESR1 are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.,PTM:Glycosylated; contains N-acetylglucosamine, probably O-linked.,PTM:Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcri
Subcellular Location[Isoform 1]: Nucleus . Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . A minor fraction is associated with the inner membrane.; [Isoform 3]: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Single-pass type I membrane protein. Associated with the inner membrane via palmitoylation (Probable). At least a subset exists as a transmembrane protein with a N-terminal extracellular domain. .; Nucleus. Golgi apparatus. Cell membrane. Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.
ExpressionWidely expressed (PubMed:10970861). Not expressed in the pituitary gland (PubMed:10970861). ; [Isoform 3]: Widely expressed, however not expressed in the pituitary gland.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human ER-α around the non-acetylation site of Lys303. AA range:261-310
Gene NameESR1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundestrogen receptor 1(ESR1) Homo sapiens This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014],
Conjugated Antibody
This product is also available conjugated. Format: E20-75323-Conjugate. Price: $485 / Size: 100μl.
E20-75323-FITC$485 / 100μlE20-75323-Biotin$485 / 100μlE20-75323-HRP$485 / 100μlE20-75323-AP$485 / 100μlE20-75323-AF350$485 / 100μlE20-75323-AF405M$485 / 100μlE20-75323-AF488$485 / 100μlE20-75323-AF514$485 / 100μlE20-75323-AF532$485 / 100μlE20-75323-AF555$485 / 100μlE20-75323-AF568$485 / 100μlE20-75323-AF405S$485 / 100μlE20-75323-AF405L$485 / 100μlE20-75323-AF546$485 / 100μlE20-75323-AF594$485 / 100μlE20-75323-AF610$485 / 100μlE20-75323-AF635$485 / 100μlE20-75323-AF647$485 / 100μlE20-75323-AF680$485 / 100μlE20-75323-AF700$485 / 100μlE20-75323-AF750$485 / 100μlE20-75323-AF790$485 / 100μlE20-75323-APC$485 / 100μlE20-75323-PE$485 / 100μlE20-75323-Cy3$485 / 100μlE20-75323-Cy5$485 / 100μlE20-75323-Cy5.5$485 / 100μlE20-75323-Cy7$485 / 100μlE20-75323-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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