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Cell Signal Transduction Research Antibodies
NUMB Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight70804Da
Protein NameProtein numb homolog
Human Gene Id8650
Human Swiss Prot NoP49757
Mouse Gene Id18222
Mouse Swiss Prot NoQ9QZS3
Rat Swiss Prot NoQ2LC84
SpecificityNUMB Polyclonal Antibody detects endogenous levels of NUMB protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNUMB; Protein numb homolog; h-Numb; Protein S171
Observed Band(KD)70
Functionfunction:Implicated in the control of cell fate decisions during development.,PTM:Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,sequence caution:Intron retention.,similarity:Contains 1 PID domain.,subunit:Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.,
Subcellular LocationCell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to perinuclear endosomes in an AAK1-dependent manner. .
ExpressionB cells,Blood,Brain,Cervix carcinoma,Epithelium,Fetal brain,HeLa cells,Live
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the Internal region of human NUMB.
Gene NameNUMB
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
BackgroundNUMB, endocytic adaptor protein(NUMB) Homo sapiens The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
Conjugated Antibody
This product is also available conjugated. Format: E20-75320-Conjugate. Price: $485 / Size: 100μl.
E20-75320-FITC$485 / 100μlE20-75320-Biotin$485 / 100μlE20-75320-HRP$485 / 100μlE20-75320-AP$485 / 100μlE20-75320-AF350$485 / 100μlE20-75320-AF405M$485 / 100μlE20-75320-AF488$485 / 100μlE20-75320-AF514$485 / 100μlE20-75320-AF532$485 / 100μlE20-75320-AF555$485 / 100μlE20-75320-AF568$485 / 100μlE20-75320-AF405S$485 / 100μlE20-75320-AF405L$485 / 100μlE20-75320-AF546$485 / 100μlE20-75320-AF594$485 / 100μlE20-75320-AF610$485 / 100μlE20-75320-AF635$485 / 100μlE20-75320-AF647$485 / 100μlE20-75320-AF680$485 / 100μlE20-75320-AF700$485 / 100μlE20-75320-AF750$485 / 100μlE20-75320-AF790$485 / 100μlE20-75320-APC$485 / 100μlE20-75320-PE$485 / 100μlE20-75320-Cy3$485 / 100μlE20-75320-Cy5$485 / 100μlE20-75320-Cy5.5$485 / 100μlE20-75320-Cy7$485 / 100μlE20-75320-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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