Neuregulin-1 Polyclonal Antibody

Name: Neuregulin-1 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75319
Price: 225 USD
Availability: InStock

E20-75319Cite ID: EN0055452Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight70392Da

Protein NamePro-neuregulin-1 membrane-bound isoform

Human Gene Id3084

Human Swiss Prot NoQ02297

Rat Gene Id112400

Rat Swiss Prot NoP43322

SpecificityNeuregulin-1 Polyclonal Antibody detects endogenous levels of Neuregulin-1 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameNRG1; GGF; HGL; HRGA; NDF; SMDF; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1

Observed Band(KD)70

Functionalternative products:Additional isoforms seem to exist. Isoforms have been classified as type I NRGs (isoforms with an Ig domain and a glycosylation domain, isoforms 1-8), type II NRGs (isoforms with an Ig domain but no glycosylation domain, isoform 9) and type III NRGs (isoforms with a Cys-rich domain, isoform 10). All these isoforms perform distinct tissue-specific functions,developmental stage:Detectable at early embryonic ages.,disease:A rare chromosomal aberration involving NRG1 produces gamma-heregulin. Translocation t(8;11) with ODZ4. The translocation fuses the 5'-end of ODZ4 to NRG1 (isoform 8). The product of this translocation was first thought to be an alternatively spliced isoform. Gamma-heregulin is a soluble activating ligand for the ERBB2-ERBB3 receptor complex and acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175). Not detected in breas

Subcellular Location[Pro-neuregulin-1, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Does not seem to be active.; [Neuregulin-1]: Secreted.; [Isoform 8]: Nucleus. May be nuclear.; [Isoform 9]: Secreted. Has a signal peptide.; [Isoform 10]: Membrane; Single-pass type I membrane protein. May possess an internal uncleaved signal sequence.

ExpressionType I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sen

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenSynthesized peptide derived from the N-terminal region of human Neuregulin-1.

Gene NameNRG1

DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Backgroundneuregulin 1(NRG1) Homo sapiens The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75319-Conjugate. Price: $485 / Size: 100μl.

E20-75319-FITC$485 / 100μlE20-75319-Biotin$485 / 100μlE20-75319-HRP$485 / 100μlE20-75319-AP$485 / 100μlE20-75319-AF350$485 / 100μlE20-75319-AF405M$485 / 100μlE20-75319-AF488$485 / 100μlE20-75319-AF514$485 / 100μlE20-75319-AF532$485 / 100μlE20-75319-AF555$485 / 100μlE20-75319-AF568$485 / 100μlE20-75319-AF405S$485 / 100μlE20-75319-AF405L$485 / 100μlE20-75319-AF546$485 / 100μlE20-75319-AF594$485 / 100μlE20-75319-AF610$485 / 100μlE20-75319-AF635$485 / 100μlE20-75319-AF647$485 / 100μlE20-75319-AF680$485 / 100μlE20-75319-AF700$485 / 100μlE20-75319-AF750$485 / 100μlE20-75319-AF790$485 / 100μlE20-75319-APC$485 / 100μlE20-75319-PE$485 / 100μlE20-75319-Cy3$485 / 100μlE20-75319-Cy5$485 / 100μlE20-75319-Cy5.5$485 / 100μlE20-75319-Cy7$485 / 100μlE20-75319-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.