Product Information
Molecular Weight50663Da
Protein NameRab GDP dissociation inhibitor beta
Human Gene Id2665
Human Swiss Prot NoP50395
Mouse Gene Id14569
Mouse Swiss Prot NoQ61598
Rat Gene Id29662
Rat Swiss Prot NoP50399
SpecificityGDI-2 Polyclonal Antibody detects endogenous levels of GDI-2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGDI2; RABGDIB; Rab GDP dissociation inhibitor beta; Rab GDI beta; Guanosine diphosphate dissociation inhibitor 2; GDI-2
Observed Band(KD)50
Functionfunction:Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.,similarity:Belongs to the Rab GDI family.,tissue specificity:Ubiquitous.,
Subcellular LocationCytoplasm . Membrane ; Peripheral membrane protein .
ExpressionUbiquitous.
BackgroundGDP dissociation inhibitor 2(GDI2) Homo sapiens GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],