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Cell Signal Transduction Research Antibodies
Lyn Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight58443Da
Protein NameTyrosine-protein kinase Lyn
Human Gene Id4067
Human Swiss Prot NoP07948
Mouse Gene Id17096
Mouse Swiss Prot NoP25911
Rat Gene Id81515
Rat Swiss Prot NoQ07014
SpecificityLyn Polyclonal Antibody detects endogenous levels of Lyn protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameLYN; JTK8; Tyrosine-protein kinase Lyn; Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn
Observed Band(KD)58
Functioncatalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with phosphorylated LIME1 and with CD79A upon BCR activation. Interacts with Epstein-Barr virus LMP2A. Interacts with TGFB1I1. Interaction, via the SH2 and SH3, domains with MUC1 is stimulated by IL7 and, the subsequent phosphorylation increases the binding between MUC1 and CTNNB1/beta-catenin. Interacts with PPP1R15A via the SH3 domain.,tissue specificity:Expressed in primary neuroblastoma tumors.,
Subcellular LocationCell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Membrane ; Lipid-anchor . Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts.
ExpressionDetected in monocytes (at protein level). Detected in placenta, and in fetal brain, lung, liver and kidney. Widely expressed in a variety of organs, tissues, and cell types such as epidermoid, hematopoietic, and neuronal cells. Expressed in primary neuroblastoma tumors.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Lyn. AA range:149-198
Gene NameLYN
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
BackgroundLYN proto-oncogene, Src family tyrosine kinase(LYN) Homo sapiens This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75313-Conjugate. Price: $485 / Size: 100μl.
E20-75313-FITC$485 / 100μlE20-75313-Biotin$485 / 100μlE20-75313-HRP$485 / 100μlE20-75313-AP$485 / 100μlE20-75313-AF350$485 / 100μlE20-75313-AF405M$485 / 100μlE20-75313-AF488$485 / 100μlE20-75313-AF514$485 / 100μlE20-75313-AF532$485 / 100μlE20-75313-AF555$485 / 100μlE20-75313-AF568$485 / 100μlE20-75313-AF405S$485 / 100μlE20-75313-AF405L$485 / 100μlE20-75313-AF546$485 / 100μlE20-75313-AF594$485 / 100μlE20-75313-AF610$485 / 100μlE20-75313-AF635$485 / 100μlE20-75313-AF647$485 / 100μlE20-75313-AF680$485 / 100μlE20-75313-AF700$485 / 100μlE20-75313-AF750$485 / 100μlE20-75313-AF790$485 / 100μlE20-75313-APC$485 / 100μlE20-75313-PE$485 / 100μlE20-75313-Cy3$485 / 100μlE20-75313-Cy5$485 / 100μlE20-75313-Cy5.5$485 / 100μlE20-75313-Cy7$485 / 100μlE20-75313-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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