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Cell Signal Transduction Research Antibodies
Pax-5 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight42149Da
Protein NamePaired box protein Pax-5
Human Gene Id5079
Human Swiss Prot NoQ02548
Mouse Gene Id18507
Mouse Swiss Prot NoQ02650
SpecificityPax-5 Polyclonal Antibody detects endogenous levels of Pax-5 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePAX5; Paired box protein Pax-5; B-cell-specific transcription factor; BSAP
Observed Band(KD)42
Functiondevelopmental stage:Expressed at early B-cell differentiation, in the developing CNS and in adult testis.,disease:A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.,function:May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.,PTM:O-glycosylated.,similarity:Contains 1 paired domain.,subunit:Interacts with DAXX (By similarity). Binds DNA as a monomer. Binds TLE4.,
Subcellular LocationNucleus .
ExpressionMarginal zone lymphoma,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human PAX5. AA range:171-220
Gene NamePAX5
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundpaired box 5(PAX5) Homo sapiens This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer
Conjugated Antibody
This product is also available conjugated. Format: E20-75312-Conjugate. Price: $485 / Size: 100μl.
E20-75312-FITC$485 / 100μlE20-75312-Biotin$485 / 100μlE20-75312-HRP$485 / 100μlE20-75312-AP$485 / 100μlE20-75312-AF350$485 / 100μlE20-75312-AF405M$485 / 100μlE20-75312-AF488$485 / 100μlE20-75312-AF514$485 / 100μlE20-75312-AF532$485 / 100μlE20-75312-AF555$485 / 100μlE20-75312-AF568$485 / 100μlE20-75312-AF405S$485 / 100μlE20-75312-AF405L$485 / 100μlE20-75312-AF546$485 / 100μlE20-75312-AF594$485 / 100μlE20-75312-AF610$485 / 100μlE20-75312-AF635$485 / 100μlE20-75312-AF647$485 / 100μlE20-75312-AF680$485 / 100μlE20-75312-AF700$485 / 100μlE20-75312-AF750$485 / 100μlE20-75312-AF790$485 / 100μlE20-75312-APC$485 / 100μlE20-75312-PE$485 / 100μlE20-75312-Cy3$485 / 100μlE20-75312-Cy5$485 / 100μlE20-75312-Cy5.5$485 / 100μlE20-75312-Cy7$485 / 100μlE20-75312-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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