Bcl-6 Polyclonal Antibody

Name: Bcl-6 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75311
Price: 225 USD
Availability: InStock

E20-75311Cite ID: EN0055444Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight78846Da

Protein NameB-cell lymphoma 6 protein

Human Gene Id604

Human Swiss Prot NoP41182

Mouse Gene Id12053

Mouse Swiss Prot NoP41183

SpecificityBcl-6 Polyclonal Antibody detects endogenous levels of Bcl-6 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameBCL6; BCL5; LAZ3; ZBTB27; ZNF51; B-cell lymphoma 6 protein; BCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51

Observed Band(KD)78

Functiondisease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.,disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.,disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.,function:Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.,induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan.,PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.,similarity:Cont

Subcellular LocationNucleus .

ExpressionExpressed in germinal center T- and B-cells and in primary immature dendritic cells.

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human BCL6. AA range:271-320

Gene NameBCL6

DilutionIF: 1:50-200 Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

BackgroundB-cell CLL/lymphoma 6(BCL6) Homo sapiens The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75311-Conjugate. Price: $485 / Size: 100μl.

E20-75311-FITC$485 / 100μlE20-75311-Biotin$485 / 100μlE20-75311-HRP$485 / 100μlE20-75311-AP$485 / 100μlE20-75311-AF350$485 / 100μlE20-75311-AF405M$485 / 100μlE20-75311-AF488$485 / 100μlE20-75311-AF514$485 / 100μlE20-75311-AF532$485 / 100μlE20-75311-AF555$485 / 100μlE20-75311-AF568$485 / 100μlE20-75311-AF405S$485 / 100μlE20-75311-AF405L$485 / 100μlE20-75311-AF546$485 / 100μlE20-75311-AF594$485 / 100μlE20-75311-AF610$485 / 100μlE20-75311-AF635$485 / 100μlE20-75311-AF647$485 / 100μlE20-75311-AF680$485 / 100μlE20-75311-AF700$485 / 100μlE20-75311-AF750$485 / 100μlE20-75311-AF790$485 / 100μlE20-75311-APC$485 / 100μlE20-75311-PE$485 / 100μlE20-75311-Cy3$485 / 100μlE20-75311-Cy5$485 / 100μlE20-75311-Cy5.5$485 / 100μlE20-75311-Cy7$485 / 100μlE20-75311-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.