World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
GDF-5 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight55411Da
Protein NameGrowth/differentiation factor 5
Human Gene Id8200
Human Swiss Prot NoP43026
Mouse Gene Id14563
Mouse Swiss Prot NoP43027
SpecificityGDF-5 Polyclonal Antibody detects endogenous levels of GDF-5 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGDF5; CDMP1; Growth/differentiation factor 5; GDF-5; Cartilage-derived morphogenetic protein 1; CDMP-1; Radotermin
Observed Band(KD)55
Functiondisease:Defects in GDF5 are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits.,disease:Defects in GDF5 are a cause of symphalangism proximal syndrome (SYM1) [MIM:185800]. SYM1 is characterized by the hereditary absence of the proximal interphalangeal (PIP) joints (Cushing symphalangism). Severity of PIP joint involvement diminishes towards the radial side. Distal interphalangeal joints are less frequently involved and metacarpophalangeal joints are rarely affected whereas carpal bone malformation and fusion are common. In the lower extremities,
Subcellular LocationSecreted . Cell membrane .
ExpressionPredominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human GDF5. AA range:361-410
Gene NameGDF5
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundgrowth differentiation factor 5(GDF5) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis. [provided by RefSeq, Aug 2016],
Conjugated Antibody
This product is also available conjugated. Format: E20-75302-Conjugate. Price: $485 / Size: 100μl.
E20-75302-FITC$485 / 100μlE20-75302-Biotin$485 / 100μlE20-75302-HRP$485 / 100μlE20-75302-AP$485 / 100μlE20-75302-AF350$485 / 100μlE20-75302-AF405M$485 / 100μlE20-75302-AF488$485 / 100μlE20-75302-AF514$485 / 100μlE20-75302-AF532$485 / 100μlE20-75302-AF555$485 / 100μlE20-75302-AF568$485 / 100μlE20-75302-AF405S$485 / 100μlE20-75302-AF405L$485 / 100μlE20-75302-AF546$485 / 100μlE20-75302-AF594$485 / 100μlE20-75302-AF610$485 / 100μlE20-75302-AF635$485 / 100μlE20-75302-AF647$485 / 100μlE20-75302-AF680$485 / 100μlE20-75302-AF700$485 / 100μlE20-75302-AF750$485 / 100μlE20-75302-AF790$485 / 100μlE20-75302-APC$485 / 100μlE20-75302-PE$485 / 100μlE20-75302-Cy3$485 / 100μlE20-75302-Cy5$485 / 100μlE20-75302-Cy5.5$485 / 100μlE20-75302-Cy7$485 / 100μlE20-75302-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits