Product Information
Molecular Weight51444Da
Protein NameGrowth/differentiation factor 9
Human Gene Id2661
Human Swiss Prot NoO60383
Mouse Gene Id14566
Mouse Swiss Prot NoQ07105
SpecificityGDF-9 Polyclonal Antibody detects endogenous levels of GDF-9 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGDF9; Growth/differentiation factor 9; GDF-9
Observed Band(KD)51
Functionfunction:Required for ovarian folliculogenesis.,similarity:Belongs to the TGF-beta family.,subunit:Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.,
Subcellular LocationSecreted .
ExpressionExpressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level).
Backgroundgrowth differentiation factor 9(GDF9) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Reduced expression of this gene may be associated with polycystic ovary syndrome and mutations in this gene may be more common in mothers of dizygotic twins. [provided by RefSeq, Jul 2016],