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Cell Signal Transduction Research Antibodies
MACC1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight96639Da
Protein NameMetastasis-associated in colon cancer protein 1
Human Gene Id346389
Human Swiss Prot NoQ6ZN28
SpecificityMACC1 Polyclonal Antibody detects endogenous levels of MACC1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMACC1; Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5
Observed Band(KD)97
Functionfunction:Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly found in the cytoplasm in non-metastasizing tumors.,tissue specificity:Preferentially expressed in metastasizing tumors.,
Subcellular LocationCytoplasm . Nucleus . Mainly found in the cytoplasm in non-metastasizing tumors.
ExpressionPreferentially expressed in metastasizing tumors.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human MACC1. AA range:411-460
Gene NameMACC1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
BackgroundMACC1, MET transcriptional regulator(MACC1) Homo sapiens MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009],
Conjugated Antibody
This product is also available conjugated. Format: E20-75292-Conjugate. Price: $485 / Size: 100μl.
E20-75292-FITC$485 / 100μlE20-75292-Biotin$485 / 100μlE20-75292-HRP$485 / 100μlE20-75292-AP$485 / 100μlE20-75292-AF350$485 / 100μlE20-75292-AF405M$485 / 100μlE20-75292-AF488$485 / 100μlE20-75292-AF514$485 / 100μlE20-75292-AF532$485 / 100μlE20-75292-AF555$485 / 100μlE20-75292-AF568$485 / 100μlE20-75292-AF405S$485 / 100μlE20-75292-AF405L$485 / 100μlE20-75292-AF546$485 / 100μlE20-75292-AF594$485 / 100μlE20-75292-AF610$485 / 100μlE20-75292-AF635$485 / 100μlE20-75292-AF647$485 / 100μlE20-75292-AF680$485 / 100μlE20-75292-AF700$485 / 100μlE20-75292-AF750$485 / 100μlE20-75292-AF790$485 / 100μlE20-75292-APC$485 / 100μlE20-75292-PE$485 / 100μlE20-75292-Cy3$485 / 100μlE20-75292-Cy5$485 / 100μlE20-75292-Cy5.5$485 / 100μlE20-75292-Cy7$485 / 100μlE20-75292-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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