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Cell Signal Transduction Research Antibodies
CKR-4 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight41403Da
Protein NameC-C chemokine receptor type 4
Human Gene Id1233
Human Swiss Prot NoP51679
Mouse Gene Id12773
Mouse Swiss Prot NoP51680
SpecificityCKR-4 Polyclonal Antibody detects endogenous levels of CKR-4 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCCR4; CMKBR4; C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; K5-5; CD194
Observed Band(KD)41
Functionfunction:High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.,online information:CC chemokine receptors entry,PTM:In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected a
Subcellular LocationCell membrane; Multi-pass membrane protein.
ExpressionPredominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human CCR4. AA range:1-50
Gene NameCCR4
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
BackgroundC-C motif chemokine receptor 4(CCR4) Homo sapiens The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75290-Conjugate. Price: $485 / Size: 100μl.
E20-75290-FITC$485 / 100μlE20-75290-Biotin$485 / 100μlE20-75290-HRP$485 / 100μlE20-75290-AP$485 / 100μlE20-75290-AF350$485 / 100μlE20-75290-AF405M$485 / 100μlE20-75290-AF488$485 / 100μlE20-75290-AF514$485 / 100μlE20-75290-AF532$485 / 100μlE20-75290-AF555$485 / 100μlE20-75290-AF568$485 / 100μlE20-75290-AF405S$485 / 100μlE20-75290-AF405L$485 / 100μlE20-75290-AF546$485 / 100μlE20-75290-AF594$485 / 100μlE20-75290-AF610$485 / 100μlE20-75290-AF635$485 / 100μlE20-75290-AF647$485 / 100μlE20-75290-AF680$485 / 100μlE20-75290-AF700$485 / 100μlE20-75290-AF750$485 / 100μlE20-75290-AF790$485 / 100μlE20-75290-APC$485 / 100μlE20-75290-PE$485 / 100μlE20-75290-Cy3$485 / 100μlE20-75290-Cy5$485 / 100μlE20-75290-Cy5.5$485 / 100μlE20-75290-Cy7$485 / 100μlE20-75290-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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