CD159a/c Polyclonal Antibody

Name: CD159a/c Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75288
Price: 225 USD
Availability: InStock

E20-75288Cite ID: EN0055421Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight26287Da

Protein NameNKG2-A/NKG2-B type II integral membrane protein/NKG2-C type II integral membrane protein/NKG2-E type II integral membrane protein

Human Gene Id3821

Human Swiss Prot NoP26715

SpecificityCD159a/c Polyclonal Antibody detects endogenous levels of CD159a/c protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameKLRC1; NKG2A; NKG2-A/NKG2-B type II integral membrane protein; CD159 antigen-like family member A; NK cell receptor A; NKG2-A/B-activating NK receptor; CD159a; KLRC2; NKG2C; NKG2-C type II integral membrane protein;CD159 antigen-like family member C; NK cell receptor C; NKG2-C-activating NK receptor; CD159c; KLRC3; NKG2E; NKG2-E type II integral membrane protein; NK cell receptor E; NKG2-E-activating NK receptor

Observed Band(KD)25

Functionfunction:Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.,online information:NKG-2A,similarity:Contains 1 C-type lectin domain.,subunit:Can form disulfide-bonded heterodimer with CD94.,tissue specificity:Natural killer cells.,

Subcellular LocationCell membrane ; Single-pass type II membrane protein .

ExpressionPredominantly expressed in NK cells (at protein level) (PubMed:9430220, PubMed:9485206, PubMed:20952657). Expressed in intraepithelial CD8-positive T cell subsets with higher frequency in gamma-delta T cells than alpha-beta T cells (at protein level) (PubMed:18064301). Expressed in memory gamma-delta T cells (at protein level) (PubMed:20952657). Restricted to a subset of memory/effector CD8-positive alpha-beta T cells (at protein level) (PubMed:12387742). Expressed in intratumoral NK and CD8-positive T cells (PubMed:30503213). Expressed in melanoma-specific cytotoxic T cell clones (at protein level) (PubMed:9485206). KLRD1-KLRC1 and KLRD1-KLRC2 are differentially expressed in NK and T cell populations, with only minor subsets expressing both receptor complexes (at protein level) (PubMed:20

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human KLRC1/2/3. AA range:101-150

Gene NameKLRC1/KLRC2/KLRC3

DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

Backgroundkiller cell lectin like receptor C1(KLRC1) Homo sapiens Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provide

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75288-Conjugate. Price: $485 / Size: 100μl.

E20-75288-FITC$485 / 100μlE20-75288-Biotin$485 / 100μlE20-75288-HRP$485 / 100μlE20-75288-AP$485 / 100μlE20-75288-AF350$485 / 100μlE20-75288-AF405M$485 / 100μlE20-75288-AF488$485 / 100μlE20-75288-AF514$485 / 100μlE20-75288-AF532$485 / 100μlE20-75288-AF555$485 / 100μlE20-75288-AF568$485 / 100μlE20-75288-AF405S$485 / 100μlE20-75288-AF405L$485 / 100μlE20-75288-AF546$485 / 100μlE20-75288-AF594$485 / 100μlE20-75288-AF610$485 / 100μlE20-75288-AF635$485 / 100μlE20-75288-AF647$485 / 100μlE20-75288-AF680$485 / 100μlE20-75288-AF700$485 / 100μlE20-75288-AF750$485 / 100μlE20-75288-AF790$485 / 100μlE20-75288-APC$485 / 100μlE20-75288-PE$485 / 100μlE20-75288-Cy3$485 / 100μlE20-75288-Cy5$485 / 100μlE20-75288-Cy5.5$485 / 100μlE20-75288-Cy7$485 / 100μlE20-75288-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.