Product Information
Molecular Weight26671Da
Protein NameEndothelial protein C receptor
Human Gene Id10544
Human Swiss Prot NoQ9UNN8
Mouse Gene Id19124
Mouse Swiss Prot NoQ64695
Rat Gene Id362248
Rat Swiss Prot NoQ4V8I1
SpecificityCD201 Polyclonal Antibody detects endogenous levels of CD201 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePROCR; EPCR; Endothelial protein C receptor; Activated protein C receptor; APC receptor; Endothelial cell protein C receptor; CD201
Observed Band(KD)26
Functionfunction:Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.,PTM:A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.,PTM:N-glycosylated.,tissue specificity:Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.,
Subcellular LocationMembrane; Single-pass type I membrane protein.
ExpressionExpressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.
Backgroundprotein C receptor(PROCR) Homo sapiens The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013],