World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
CD276 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight(Da):57235
Protein NameCD276 antigen
Human Gene Id80381
Human Swiss Prot NoQ5ZPR3
Mouse Gene Id102657
Mouse Swiss Prot NoQ8VE98
Rat Gene Id315716
Rat Swiss Prot NoQ7TPB4
SpecificityCD276 Polyclonal Antibody detects endogenous levels of CD276 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCD276; B7H3; PSEC0249; CD276 antigen; 4Ig-B7-H3; B7 homolog 3; B7-H3; Costimulatory molecule; CD276
Observed Band(KD)57
Functionfunction:May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.,induction:By LPS in monocytes and by ionomycin in T and B lymphocytes. Up-regulated in cells mediating rejection of human tr
Subcellular LocationMembrane ; Single-pass type I membrane protein .
ExpressionUbiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CD276. AA range:271-320
Gene NameCD276
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
BackgroundCD276 molecule(CD276) Homo sapiens The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75285-Conjugate. Price: $485 / Size: 100μl.
E20-75285-FITC$485 / 100μlE20-75285-Biotin$485 / 100μlE20-75285-HRP$485 / 100μlE20-75285-AP$485 / 100μlE20-75285-AF350$485 / 100μlE20-75285-AF405M$485 / 100μlE20-75285-AF488$485 / 100μlE20-75285-AF514$485 / 100μlE20-75285-AF532$485 / 100μlE20-75285-AF555$485 / 100μlE20-75285-AF568$485 / 100μlE20-75285-AF405S$485 / 100μlE20-75285-AF405L$485 / 100μlE20-75285-AF546$485 / 100μlE20-75285-AF594$485 / 100μlE20-75285-AF610$485 / 100μlE20-75285-AF635$485 / 100μlE20-75285-AF647$485 / 100μlE20-75285-AF680$485 / 100μlE20-75285-AF700$485 / 100μlE20-75285-AF750$485 / 100μlE20-75285-AF790$485 / 100μlE20-75285-APC$485 / 100μlE20-75285-PE$485 / 100μlE20-75285-Cy3$485 / 100μlE20-75285-Cy5$485 / 100μlE20-75285-Cy5.5$485 / 100μlE20-75285-Cy7$485 / 100μlE20-75285-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits