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Cell Signal Transduction Research Antibodies
CD328 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight51143Da
Protein NameSialic acid-binding Ig-like lectin 7
Human Gene Id27036
Human Swiss Prot NoQ9Y286
SpecificityCD328 Polyclonal Antibody detects endogenous levels of CD328 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSIGLEC7; AIRM1; Sialic acid-binding Ig-like lectin 7; Siglec-7; Adhesion inhibitory receptor molecule 1; AIRM-1; CDw328; D-siglec; QA79 membrane protein; p75; CD328
Observed Band(KD)51
Functiondomain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dep
Subcellular LocationMembrane; Single-pass type I membrane protein.
ExpressionPredominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human SIGLEC7. AA range:51-100
Gene NameSIGLEC7
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgrounddomain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).,online information:Siglec-7,PTM:Tyrosine phosphorylated.,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with PTPN6/SHP-1 upon phosphorylation.,tissue specificity:Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.,
Conjugated Antibody
This product is also available conjugated. Format: E20-75281-Conjugate. Price: $485 / Size: 100μl.
E20-75281-FITC$485 / 100μlE20-75281-Biotin$485 / 100μlE20-75281-HRP$485 / 100μlE20-75281-AP$485 / 100μlE20-75281-AF350$485 / 100μlE20-75281-AF405M$485 / 100μlE20-75281-AF488$485 / 100μlE20-75281-AF514$485 / 100μlE20-75281-AF532$485 / 100μlE20-75281-AF555$485 / 100μlE20-75281-AF568$485 / 100μlE20-75281-AF405S$485 / 100μlE20-75281-AF405L$485 / 100μlE20-75281-AF546$485 / 100μlE20-75281-AF594$485 / 100μlE20-75281-AF610$485 / 100μlE20-75281-AF635$485 / 100μlE20-75281-AF647$485 / 100μlE20-75281-AF680$485 / 100μlE20-75281-AF700$485 / 100μlE20-75281-AF750$485 / 100μlE20-75281-AF790$485 / 100μlE20-75281-APC$485 / 100μlE20-75281-PE$485 / 100μlE20-75281-Cy3$485 / 100μlE20-75281-Cy5$485 / 100μlE20-75281-Cy5.5$485 / 100μlE20-75281-Cy7$485 / 100μlE20-75281-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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