Frizzled-10 Polyclonal Antibody

Name: Frizzled-10 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75280
Price: 225 USD
Availability: InStock

E20-75280Cite ID: EN0055413Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight65336Da

Protein NameFrizzled-10

Human Gene Id11211

Human Swiss Prot NoQ9ULW2

Mouse Gene Id93897

Mouse Swiss Prot NoQ8BKG4

SpecificityFrizzled-10 Polyclonal Antibody detects endogenous levels of Frizzled-10 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameFZD10; Frizzled-10; Fz-10; hFz10; FzE7; CD350

Observed Band(KD)65

Functiondomain:Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.,domain:The FZ domain is involved in binding with Wnt ligands.,function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphog

Subcellular LocationCell membrane ; Multi-pass membrane protein .

ExpressionHighest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human FZD10. AA range:31-80

Gene NameFZD10

DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

Backgroundfrizzled class receptor 10(FZD10) Homo sapiens This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75280-Conjugate. Price: $485 / Size: 100μl.

E20-75280-FITC$485 / 100μlE20-75280-Biotin$485 / 100μlE20-75280-HRP$485 / 100μlE20-75280-AP$485 / 100μlE20-75280-AF350$485 / 100μlE20-75280-AF405M$485 / 100μlE20-75280-AF488$485 / 100μlE20-75280-AF514$485 / 100μlE20-75280-AF532$485 / 100μlE20-75280-AF555$485 / 100μlE20-75280-AF568$485 / 100μlE20-75280-AF405S$485 / 100μlE20-75280-AF405L$485 / 100μlE20-75280-AF546$485 / 100μlE20-75280-AF594$485 / 100μlE20-75280-AF610$485 / 100μlE20-75280-AF635$485 / 100μlE20-75280-AF647$485 / 100μlE20-75280-AF680$485 / 100μlE20-75280-AF700$485 / 100μlE20-75280-AF750$485 / 100μlE20-75280-AF790$485 / 100μlE20-75280-APC$485 / 100μlE20-75280-PE$485 / 100μlE20-75280-Cy3$485 / 100μlE20-75280-Cy5$485 / 100μlE20-75280-Cy5.5$485 / 100μlE20-75280-Cy7$485 / 100μlE20-75280-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.