World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
SLAM Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight37231Da
Protein NameSignaling lymphocytic activation molecule
Human Gene Id6504
Human Swiss Prot NoQ13291
Mouse Gene Id27218
Mouse Swiss Prot NoQ9QUM4
SpecificitySLAM Polyclonal Antibody detects endogenous levels of SLAM protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSLAMF1; SLAM; Signaling lymphocytic activation molecule; CDw150; IPO-3; CD150
Observed Band(KD)37
Functiondomain:The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues.,function:High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.,PTM:Phosphorylated by FYN.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subcellular location:Present on the surface of B-cells and T-cells.,subunit:Its cytoplasmic domain interacts with SH2 domain protein 1A (SH2D1A), and with PTPN11. Interacts with INPP5D/SHIP
Subcellular LocationCell membrane ; Single-pass type I membrane protein. Present on the surface of B-cells and T-cells. Located at the plasma membrane contacts between neighboring T-cells (PubMed:11806999). .; [Isoform 3]: Secreted .; [Isoform 4]: Cell membrane . Overexpressed isoform 4 is detected on the cell surface. In glioma cell lines endogenuous isoform 4 is detetced predominantly in the cytoplasm and colocalized with endoplasmic reticulum and Golgi markers. .
ExpressionConstitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation (PubMed:7617038). Activated B-cells express isoform 1, isoform 3 and a cytoplasmic isoform (PubMed:9091591). Isoform 4 is expressed in B-cells, primary T-cells, dendritic cells and macrophages. Isoform 4 is expressed in tumors of the central nervous system (PubMed:25710480).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human SLAMF1. AA range:81-130
Gene NameSLAMF1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgrounddomain:The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues.,function:High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.,PTM:Phosphorylated by FYN.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subcellular location:Present on the surface of B-cells and T-cells.,subunit:Its cytoplasmic domain interacts with SH2 domain protein 1A (SH2D1A), and with PTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus HN protein and acts as a receptor for this virus.,tissue specificity:Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes, and a proportion of B-cells, and is rapidely induced on naive T-cells after activation.,
Conjugated Antibody
This product is also available conjugated. Format: E20-75279-Conjugate. Price: $485 / Size: 100μl.
E20-75279-FITC$485 / 100μlE20-75279-Biotin$485 / 100μlE20-75279-HRP$485 / 100μlE20-75279-AP$485 / 100μlE20-75279-AF350$485 / 100μlE20-75279-AF405M$485 / 100μlE20-75279-AF488$485 / 100μlE20-75279-AF514$485 / 100μlE20-75279-AF532$485 / 100μlE20-75279-AF555$485 / 100μlE20-75279-AF568$485 / 100μlE20-75279-AF405S$485 / 100μlE20-75279-AF405L$485 / 100μlE20-75279-AF546$485 / 100μlE20-75279-AF594$485 / 100μlE20-75279-AF610$485 / 100μlE20-75279-AF635$485 / 100μlE20-75279-AF647$485 / 100μlE20-75279-AF680$485 / 100μlE20-75279-AF700$485 / 100μlE20-75279-AF750$485 / 100μlE20-75279-AF790$485 / 100μlE20-75279-APC$485 / 100μlE20-75279-PE$485 / 100μlE20-75279-Cy3$485 / 100μlE20-75279-Cy5$485 / 100μlE20-75279-Cy5.5$485 / 100μlE20-75279-Cy7$485 / 100μlE20-75279-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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