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Cell Signal Transduction Research Antibodies
CD329 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight54042Da
Protein NameSialic acid-binding Ig-like lectin 8
Human Gene Id27181
Human Swiss Prot NoQ9NYZ4
SpecificityCD329 Polyclonal Antibody detects endogenous levels of CD329 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSIGLEC8; SAF2; Sialic acid-binding Ig-like lectin 8; Siglec-8; CDw329; Sialoadhesin family member 2; SAF-2; CD329
Observed Band(KD)50
Functiondomain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.,online information:Siglec-8,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expressed specifically on eosin
Subcellular LocationMembrane; Single-pass type I membrane protein.
ExpressionExpressed specifically on red blood cells namely basophil, mast cells and eosinophils.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human SIGLEC8. AA range:81-130
Gene NameSIGLEC8
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundsialic acid binding Ig like lectin 8(SIGLEC8) Homo sapiens Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-75278-Conjugate. Price: $485 / Size: 100μl.
E20-75278-FITC$485 / 100μlE20-75278-Biotin$485 / 100μlE20-75278-HRP$485 / 100μlE20-75278-AP$485 / 100μlE20-75278-AF350$485 / 100μlE20-75278-AF405M$485 / 100μlE20-75278-AF488$485 / 100μlE20-75278-AF514$485 / 100μlE20-75278-AF532$485 / 100μlE20-75278-AF555$485 / 100μlE20-75278-AF568$485 / 100μlE20-75278-AF405S$485 / 100μlE20-75278-AF405L$485 / 100μlE20-75278-AF546$485 / 100μlE20-75278-AF594$485 / 100μlE20-75278-AF610$485 / 100μlE20-75278-AF635$485 / 100μlE20-75278-AF647$485 / 100μlE20-75278-AF680$485 / 100μlE20-75278-AF700$485 / 100μlE20-75278-AF750$485 / 100μlE20-75278-AF790$485 / 100μlE20-75278-APC$485 / 100μlE20-75278-PE$485 / 100μlE20-75278-Cy3$485 / 100μlE20-75278-Cy5$485 / 100μlE20-75278-Cy5.5$485 / 100μlE20-75278-Cy7$485 / 100μlE20-75278-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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