Siglec-5/14 Polyclonal Antibody

Name: Siglec-5/14 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75270
Price: 225 USD
Availability: InStock

E20-75270Cite ID: EN0055403Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight60715/43970Da

Protein NameSialic acid-binding Ig-like lectin 5/Sialic acid-binding Ig-like lectin 14

Human Gene Id8778

Human Swiss Prot NoO15389

Mouse Swiss Prot NoQ920G3

SpecificitySiglec-5/14 Polyclonal Antibody detects endogenous levels of Siglec-5/14 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameSIGLEC5; CD33L2; OBBP2; Sialic acid-binding Ig-like lectin 5; Siglec-5; CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; OB-binding protein 2; CD170; SIGLEC14; Sialic acid-binding Ig-like lectin 14; Siglec-14

Observed Band(KD)60

Functiondomain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.,online information:Siglec-5,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expressed by monocytic/myeloid lineage cells. Found at high l

Subcellular LocationMembrane; Single-pass type I membrane protein.

ExpressionExpressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenSynthesized peptide derived from Sialic acid-binding Ig-like lectin 5/Sialic acid-binding Ig-like lectin 14 at AA range: 91-140

Gene NameSIGLEC5/SIGLEC14

DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

Backgroundsialic acid binding Ig like lectin 5(SIGLEC5) Homo sapiens This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75270-Conjugate. Price: $485 / Size: 100μl.

E20-75270-FITC$485 / 100μlE20-75270-Biotin$485 / 100μlE20-75270-HRP$485 / 100μlE20-75270-AP$485 / 100μlE20-75270-AF350$485 / 100μlE20-75270-AF405M$485 / 100μlE20-75270-AF488$485 / 100μlE20-75270-AF514$485 / 100μlE20-75270-AF532$485 / 100μlE20-75270-AF555$485 / 100μlE20-75270-AF568$485 / 100μlE20-75270-AF405S$485 / 100μlE20-75270-AF405L$485 / 100μlE20-75270-AF546$485 / 100μlE20-75270-AF594$485 / 100μlE20-75270-AF610$485 / 100μlE20-75270-AF635$485 / 100μlE20-75270-AF647$485 / 100μlE20-75270-AF680$485 / 100μlE20-75270-AF700$485 / 100μlE20-75270-AF750$485 / 100μlE20-75270-AF790$485 / 100μlE20-75270-APC$485 / 100μlE20-75270-PE$485 / 100μlE20-75270-Cy3$485 / 100μlE20-75270-Cy5$485 / 100μlE20-75270-Cy5.5$485 / 100μlE20-75270-Cy7$485 / 100μlE20-75270-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.