World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
IGF-IIR Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight274276Da
Protein NameCation-independent mannose-6-phosphate receptor
Human Gene Id3482
Human Swiss Prot NoP11717
Mouse Swiss Prot NoQ07113
SpecificityIGF-IIR Polyclonal Antibody detects endogenous levels of IGF-IIR protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameIGF2R; MPRI; Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor; MPR 300;Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD222
Observed Band(KD)250
Functiondomain:Contains 15 repeating units of approximately 147 AA. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends.,function:Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.,similarity:Belongs to the MRL1/IGF2R family.,similarity:Contains 1 fibronectin type-II domain.,subunit:Binds GGA1, GGA2 and GGA3.,
Subcellular LocationGolgi apparatus membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein . Mainly localized in the Golgi at steady state and not detectable in lysosome (PubMed:18817523). Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). .
ExpressionBrain,Epithelium,Liver,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human IGF2R. AA range:2251-2300
Gene NameIGF2R
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundinsulin like growth factor 2 receptor(IGF2R) Homo sapiens This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-75269-Conjugate. Price: $485 / Size: 100μl.
E20-75269-FITC$485 / 100μlE20-75269-Biotin$485 / 100μlE20-75269-HRP$485 / 100μlE20-75269-AP$485 / 100μlE20-75269-AF350$485 / 100μlE20-75269-AF405M$485 / 100μlE20-75269-AF488$485 / 100μlE20-75269-AF514$485 / 100μlE20-75269-AF532$485 / 100μlE20-75269-AF555$485 / 100μlE20-75269-AF568$485 / 100μlE20-75269-AF405S$485 / 100μlE20-75269-AF405L$485 / 100μlE20-75269-AF546$485 / 100μlE20-75269-AF594$485 / 100μlE20-75269-AF610$485 / 100μlE20-75269-AF635$485 / 100μlE20-75269-AF647$485 / 100μlE20-75269-AF680$485 / 100μlE20-75269-AF700$485 / 100μlE20-75269-AF750$485 / 100μlE20-75269-AF790$485 / 100μlE20-75269-APC$485 / 100μlE20-75269-PE$485 / 100μlE20-75269-Cy3$485 / 100μlE20-75269-Cy5$485 / 100μlE20-75269-Cy5.5$485 / 100μlE20-75269-Cy7$485 / 100μlE20-75269-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits