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Cell Signal Transduction Research Antibodies
GGT1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight61410Da
Protein NameGamma-glutamyltranspeptidase 1
Human Gene Id2678
Human Swiss Prot NoP19440
Mouse Swiss Prot NoQ60928
SpecificityGGT1 Polyclonal Antibody detects endogenous levels of GGT1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGGT1; GGT; Gamma-glutamyltranspeptidase 1; GGT 1; Gamma-glutamyltransferase 1; Glutathione hydrolase 1; Leukotriene-C4 hydrolase; CD224
Observed Band(KD)61
Functioncatalytic activity:(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.,disease:Defects in GGT1 are a cause of glutathionuria [MIM:231950]; also known as gamma-glutamyltranspeptidase deficiency. It is an autosomal recessive disease.,function:Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.,function:Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors.,miscellaneous:Corresponds to the light chain of other
Subcellular LocationCell membrane ; Single-pass type II membrane protein .
ExpressionDetected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.; [Isoform 3]: Lung-specific.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human GGT1. AA range:21-70
Gene NameGGT1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Backgroundgamma-glutamyltransferase 1(GGT1) Homo sapiens The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014],
Conjugated Antibody
This product is also available conjugated. Format: E20-75266-Conjugate. Price: $485 / Size: 100μl.
E20-75266-FITC$485 / 100μlE20-75266-Biotin$485 / 100μlE20-75266-HRP$485 / 100μlE20-75266-AP$485 / 100μlE20-75266-AF350$485 / 100μlE20-75266-AF405M$485 / 100μlE20-75266-AF488$485 / 100μlE20-75266-AF514$485 / 100μlE20-75266-AF532$485 / 100μlE20-75266-AF555$485 / 100μlE20-75266-AF568$485 / 100μlE20-75266-AF405S$485 / 100μlE20-75266-AF405L$485 / 100μlE20-75266-AF546$485 / 100μlE20-75266-AF594$485 / 100μlE20-75266-AF610$485 / 100μlE20-75266-AF635$485 / 100μlE20-75266-AF647$485 / 100μlE20-75266-AF680$485 / 100μlE20-75266-AF700$485 / 100μlE20-75266-AF750$485 / 100μlE20-75266-AF790$485 / 100μlE20-75266-APC$485 / 100μlE20-75266-PE$485 / 100μlE20-75266-Cy3$485 / 100μlE20-75266-Cy5$485 / 100μlE20-75266-Cy5.5$485 / 100μlE20-75266-Cy7$485 / 100μlE20-75266-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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