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Cell Signal Transduction Research Antibodies
Nectin 3 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight61002Da
Protein NamePoliovirus receptor-related protein 3
Human Gene Id25945
Human Swiss Prot NoQ9NQS3
Mouse Gene Id58998
Mouse Swiss Prot NoQ9JLB9
SpecificityNectin 3 Polyclonal Antibody detects endogenous levels of Nectin 3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePVRL3; PRR3; Poliovirus receptor-related protein 3; CDw113; Nectin-3; CD113
Observed Band(KD)60
Functionfunction:Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR
Subcellular LocationCell membrane ; Single-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane .
ExpressionPredominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human PVRL3. AA range:311-360
Gene NamePVRL3
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundnectin cell adhesion molecule 3(NECTIN3) Homo sapiens This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75261-Conjugate. Price: $485 / Size: 100μl.
E20-75261-FITC$485 / 100μlE20-75261-Biotin$485 / 100μlE20-75261-HRP$485 / 100μlE20-75261-AP$485 / 100μlE20-75261-AF350$485 / 100μlE20-75261-AF405M$485 / 100μlE20-75261-AF488$485 / 100μlE20-75261-AF514$485 / 100μlE20-75261-AF532$485 / 100μlE20-75261-AF555$485 / 100μlE20-75261-AF568$485 / 100μlE20-75261-AF405S$485 / 100μlE20-75261-AF405L$485 / 100μlE20-75261-AF546$485 / 100μlE20-75261-AF594$485 / 100μlE20-75261-AF610$485 / 100μlE20-75261-AF635$485 / 100μlE20-75261-AF647$485 / 100μlE20-75261-AF680$485 / 100μlE20-75261-AF700$485 / 100μlE20-75261-AF750$485 / 100μlE20-75261-AF790$485 / 100μlE20-75261-APC$485 / 100μlE20-75261-PE$485 / 100μlE20-75261-Cy3$485 / 100μlE20-75261-Cy5$485 / 100μlE20-75261-Cy5.5$485 / 100μlE20-75261-Cy7$485 / 100μlE20-75261-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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