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Cell Signal Transduction Research Antibodies
CD84 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight38782Da
Protein NameSLAM family member 5
Human Gene Id8832
Human Swiss Prot NoQ9UIB8
Mouse Gene Id12523
Mouse Swiss Prot NoQ18PI6
SpecificityCD84 Polyclonal Antibody detects endogenous levels of CD84 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCD84; SLAMF5; SLAM family member 5; Cell surface antigen MAX.3; Hly9-beta; Leukocyte differentiation antigen CD84; Signaling lymphocytic activation molecule 5; CD84
Observed Band(KD)39
Functiondevelopmental stage:Expression is slightly increased in naive B-cells after the first dividion. By contrast, expression on memory B-cells decreased with each successive division.,domain:ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A.,function:Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.,PTM:N-glycosylated.,PTM:Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal
Subcellular LocationCell membrane ; Single-pass type I membrane protein .
ExpressionPredominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. Expressed in mast cells.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CD84. AA range:131-180
Gene NameCD84
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
BackgroundCD84 molecule(CD84) Homo sapiens This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75256-Conjugate. Price: $485 / Size: 100μl.
E20-75256-FITC$485 / 100μlE20-75256-Biotin$485 / 100μlE20-75256-HRP$485 / 100μlE20-75256-AP$485 / 100μlE20-75256-AF350$485 / 100μlE20-75256-AF405M$485 / 100μlE20-75256-AF488$485 / 100μlE20-75256-AF514$485 / 100μlE20-75256-AF532$485 / 100μlE20-75256-AF555$485 / 100μlE20-75256-AF568$485 / 100μlE20-75256-AF405S$485 / 100μlE20-75256-AF405L$485 / 100μlE20-75256-AF546$485 / 100μlE20-75256-AF594$485 / 100μlE20-75256-AF610$485 / 100μlE20-75256-AF635$485 / 100μlE20-75256-AF647$485 / 100μlE20-75256-AF680$485 / 100μlE20-75256-AF700$485 / 100μlE20-75256-AF750$485 / 100μlE20-75256-AF790$485 / 100μlE20-75256-APC$485 / 100μlE20-75256-PE$485 / 100μlE20-75256-Cy3$485 / 100μlE20-75256-Cy5$485 / 100μlE20-75256-Cy5.5$485 / 100μlE20-75256-Cy7$485 / 100μlE20-75256-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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