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Cell Signal Transduction Research Antibodies
CD79b Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight26048Da
Protein NameB-cell antigen receptor complex-associated protein beta chain
Human Gene Id974
Human Swiss Prot NoP40259
Mouse Swiss Prot NoP15530
SpecificityCD79b Polyclonal Antibody detects endogenous levels of CD79b protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCD79B; B29; IGB; B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; CD79b
Observed Band(KD)37
Functiondisease:Defects in CD79B are a cause of non-Bruton type agammaglobulinemia [MIM:601495]. Agammaglobulinemia is an immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells.,function:Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.,online information:CD79B mutation db,PTM:Phosphorylated on tyrosine upon B-cell activation.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subcellular location:Following antigen binding, the BCR has b
Subcellular LocationCell membrane; Single-pass type I membrane protein. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. .
ExpressionB-cells.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CD79B. AA range:61-110
Gene NameCD79B
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
BackgroundCD79b molecule(CD79B) Homo sapiens The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75255-Conjugate. Price: $485 / Size: 100μl.
E20-75255-FITC$485 / 100μlE20-75255-Biotin$485 / 100μlE20-75255-HRP$485 / 100μlE20-75255-AP$485 / 100μlE20-75255-AF350$485 / 100μlE20-75255-AF405M$485 / 100μlE20-75255-AF488$485 / 100μlE20-75255-AF514$485 / 100μlE20-75255-AF532$485 / 100μlE20-75255-AF555$485 / 100μlE20-75255-AF568$485 / 100μlE20-75255-AF405S$485 / 100μlE20-75255-AF405L$485 / 100μlE20-75255-AF546$485 / 100μlE20-75255-AF594$485 / 100μlE20-75255-AF610$485 / 100μlE20-75255-AF635$485 / 100μlE20-75255-AF647$485 / 100μlE20-75255-AF680$485 / 100μlE20-75255-AF700$485 / 100μlE20-75255-AF750$485 / 100μlE20-75255-AF790$485 / 100μlE20-75255-APC$485 / 100μlE20-75255-PE$485 / 100μlE20-75255-Cy3$485 / 100μlE20-75255-Cy5$485 / 100μlE20-75255-Cy5.5$485 / 100μlE20-75255-Cy7$485 / 100μlE20-75255-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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