Product Information
Molecular Weight28147Da
Protein NameLymphocyte function-associated antigen 3
Human Gene Id965
Human Swiss Prot NoP19256
SpecificityCD58 Polyclonal Antibody detects endogenous levels of CD58 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCD58; LFA3; Lymphocyte function-associated antigen 3; Ag3; Surface glycoprotein LFA-3; CD58
Observed Band(KD)27
Functionfunction:Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,
Subcellular Location[Isoform 1]: Cell membrane; Single-pass type I membrane protein.
ExpressionBrain,Erythrocyte,
BackgroundCD58 molecule(CD58) Homo sapiens This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009],