Integrin α4 Polyclonal Antibody

Name: Integrin α4 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75248
Price: 225 USD
Availability: InStock

E20-75248Cite ID: EN0055381Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight115333Da

Protein NameIntegrin alpha-4

Human Gene Id3676

Human Swiss Prot NoP13612

Mouse Gene Id16401

Mouse Swiss Prot NoQ00651

SpecificityIntegrin α4 Polyclonal Antibody detects endogenous levels of Integrin α4 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameITGA4; CD49D; Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD49d

Observed Band(KD)120

Functiondomain:The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.,function:Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.,PTM:Phosphorylation on Ser-1027 inhibits PXN binding.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit

Subcellular LocationMembrane; Single-pass type I membrane protein.

ExpressionLymph,Peripheral blood,Prostate,Spleen,Testis,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human ITGA4. AA range:571-620

Gene NameITGA4

DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

Backgroundintegrin subunit alpha 4(ITGA4) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75248-Conjugate. Price: $485 / Size: 100μl.

E20-75248-FITC$485 / 100μlE20-75248-Biotin$485 / 100μlE20-75248-HRP$485 / 100μlE20-75248-AP$485 / 100μlE20-75248-AF350$485 / 100μlE20-75248-AF405M$485 / 100μlE20-75248-AF488$485 / 100μlE20-75248-AF514$485 / 100μlE20-75248-AF532$485 / 100μlE20-75248-AF555$485 / 100μlE20-75248-AF568$485 / 100μlE20-75248-AF405S$485 / 100μlE20-75248-AF405L$485 / 100μlE20-75248-AF546$485 / 100μlE20-75248-AF594$485 / 100μlE20-75248-AF610$485 / 100μlE20-75248-AF635$485 / 100μlE20-75248-AF647$485 / 100μlE20-75248-AF680$485 / 100μlE20-75248-AF700$485 / 100μlE20-75248-AF750$485 / 100μlE20-75248-AF790$485 / 100μlE20-75248-APC$485 / 100μlE20-75248-PE$485 / 100μlE20-75248-Cy3$485 / 100μlE20-75248-Cy5$485 / 100μlE20-75248-Cy5.5$485 / 100μlE20-75248-Cy7$485 / 100μlE20-75248-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.