Product Information
Molecular Weight25066Da
Protein NameT-cell-specific surface glycoprotein CD28
Human Gene Id940
Human Swiss Prot NoP10747
Mouse Swiss Prot NoP31041
SpecificityCD28 Polyclonal Antibody detects endogenous levels of CD28 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCD28; T-cell-specific surface glycoprotein CD28; TP44; CD28
Observed Band(KD)25
Functionfunction:Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.,online information:CD28 entry,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70.,tissue specificity:Expressed in T-cells and plasma cells, but not in less mature B-cells.,
Subcellular LocationMembrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface .
ExpressionExpressed in T-cells and plasma cells, but not in less mature B-cells.
BackgroundCD28 molecule(CD28) Homo sapiens The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011],