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Cell Signal Transduction Research Antibodies
CD1D Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight37717Da
Protein NameAntigen-presenting glycoprotein CD1d
Human Gene Id912
Human Swiss Prot NoP15813
SpecificityCD1D Polyclonal Antibody detects endogenous levels of CD1D protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCD1D; Antigen-presenting glycoprotein CD1d; R3G1; CD1d
Observed Band(KD)37
Functionfunction:Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.,miscellaneous:During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,subcellular location:Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.,subunit:Heterodimer with B2M (beta-2-microglobulin). Interacts with MHC II.,tissue specificity:Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.,
Subcellular LocationCell membrane ; Single-pass type I membrane protein . Basolateral cell membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein . Lysosome membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. .
ExpressionExpressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from Antigen-presenting glycoprotein CD1d at AA range: 161-210
Gene NameCD1D
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
BackgroundCD1d molecule(CD1D) Homo sapiens This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016],
Conjugated Antibody
This product is also available conjugated. Format: E20-75239-Conjugate. Price: $485 / Size: 100μl.
E20-75239-FITC$485 / 100μlE20-75239-Biotin$485 / 100μlE20-75239-HRP$485 / 100μlE20-75239-AP$485 / 100μlE20-75239-AF350$485 / 100μlE20-75239-AF405M$485 / 100μlE20-75239-AF488$485 / 100μlE20-75239-AF514$485 / 100μlE20-75239-AF532$485 / 100μlE20-75239-AF555$485 / 100μlE20-75239-AF568$485 / 100μlE20-75239-AF405S$485 / 100μlE20-75239-AF405L$485 / 100μlE20-75239-AF546$485 / 100μlE20-75239-AF594$485 / 100μlE20-75239-AF610$485 / 100μlE20-75239-AF635$485 / 100μlE20-75239-AF647$485 / 100μlE20-75239-AF680$485 / 100μlE20-75239-AF700$485 / 100μlE20-75239-AF750$485 / 100μlE20-75239-AF790$485 / 100μlE20-75239-APC$485 / 100μlE20-75239-PE$485 / 100μlE20-75239-Cy3$485 / 100μlE20-75239-Cy5$485 / 100μlE20-75239-Cy5.5$485 / 100μlE20-75239-Cy7$485 / 100μlE20-75239-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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