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Cell Signal Transduction Research Antibodies
LASP-1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight29717Da
Protein NameLIM and SH3 domain protein 1
Human Gene Id3927
Human Swiss Prot NoQ14847
Mouse Gene Id16796
Mouse Swiss Prot NoQ61792
Rat Gene Id29278
Rat Swiss Prot NoQ99MZ8
SpecificityLASP-1 Polyclonal Antibody detects endogenous levels of LASP-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameLASP1; MLN50; LIM and SH3 domain protein 1; LASP-1; Metastatic lymph node gene 50 protein; MLN 50
Observed Band(KD)28
Functionfunction:Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.,PTM:Phosphorylated.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 nebulin repeats.,subcellular location:Associated with the F-actin rich cortical cytoskeleton.,subunit:Interacts with F-actin.,
Subcellular LocationCytoplasm, cell cortex . Cytoplasm, cytoskeleton . Associated with the F-actin rich cortical cytoskeleton. .
ExpressionEpithelium,Liver,Mammary carcinoma,Platelet,Skin,T-cell,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human LASP1. AA range:51-100
Gene NameLASP1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
BackgroundLIM and SH3 protein 1(LASP1) Homo sapiens This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012],
Conjugated Antibody
This product is also available conjugated. Format: E20-75234-Conjugate. Price: $485 / Size: 100μl.
E20-75234-FITC$485 / 100μlE20-75234-Biotin$485 / 100μlE20-75234-HRP$485 / 100μlE20-75234-AP$485 / 100μlE20-75234-AF350$485 / 100μlE20-75234-AF405M$485 / 100μlE20-75234-AF488$485 / 100μlE20-75234-AF514$485 / 100μlE20-75234-AF532$485 / 100μlE20-75234-AF555$485 / 100μlE20-75234-AF568$485 / 100μlE20-75234-AF405S$485 / 100μlE20-75234-AF405L$485 / 100μlE20-75234-AF546$485 / 100μlE20-75234-AF594$485 / 100μlE20-75234-AF610$485 / 100μlE20-75234-AF635$485 / 100μlE20-75234-AF647$485 / 100μlE20-75234-AF680$485 / 100μlE20-75234-AF700$485 / 100μlE20-75234-AF750$485 / 100μlE20-75234-AF790$485 / 100μlE20-75234-APC$485 / 100μlE20-75234-PE$485 / 100μlE20-75234-Cy3$485 / 100μlE20-75234-Cy5$485 / 100μlE20-75234-Cy5.5$485 / 100μlE20-75234-Cy7$485 / 100μlE20-75234-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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